Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures
Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures
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DOI：
10.1016/j.devcel.2006.10.004
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发表时间：
2007-01-01
影响因子：
11.8
通讯作者：
Okamoto, Hitoshi
中科院分区：
文献类型：
--
作者：
Aizawa, Hidenori;Goto, Midori;Okamoto, Hitoshi
斑马鱼间脑两侧缰核神经元向脚间核的轴突投射不对称(侧位)。我们以前发现缰核可以细分为内侧亚核和外侧亚核，这些亚核大小的显著左右差异是其神经连接不对称的原因。在本研究中，出生日期分析表明，外侧亚核的神经前体比内侧亚核的神经前体更早出生。早期出生的外侧亚核在左侧产生更多的神经元，而晚出生的内侧亚核的神经元在右侧产生更多的神经元。Notch信号的遗传过度激活和抑制表明，不同的时机决定了缰核神经前体神经发生的特异性和不对称性。
The habenular neurons on both sides of the zebrafish diencephalon show an asymmetric (laterotopic) axonal projection pattern into the interpeduncular nucleus. We previously revealed that the habenula could be subdivided into medial and lateral subnuclei, and a prominent left-right difference in the size ratio of these subnuclei accounts for the asymmetry in its neural connectivity. In the present study, birth date analysis showed that neural precursors for the lateral subnuclei were born at earlier stages than those for the medial subnuclei. More neurons for the early-born lateral subnuclei were generated on the left side, while more neurons for the late-born medial subnuclei were generated on the right side. Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei.