Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma
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DOI：
10.1136/jclinpath-2015-203025
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发表时间：
2016-04-01
影响因子：
3.4
通讯作者：
Bian, Xiu-wu
中科院分区：
文献类型：
--
作者：
Hu, Xu-gang;Chen, Lu;Bian, Xiu-wu
AMS ASCL2是一种碱性螺旋-环-螺旋(BHLH)转录因子，可能参与肿瘤的发展。本研究旨在探讨ASCL2在非小细胞癌(NSCLC)中的表达水平及其预后价值。方法采用免疫组织化学(IHC)队列法检测79例鳞癌(SCC)和67例腺癌(AC)中ASCL2蛋白的表达。采用Kaplan-Meier分析和Cox回归分析评价ASCL2的预后意义。结果ASCL2在鳞癌组织中的表达水平显著高于正常肺组织(P<0.05)。
Aims ASCL2, a basic helix-loop-helix (bHLH) transcription factor, is putatively involved in tumour progression. This study aimed to evaluate ASCL2 expression level in non-small-cell carcinoma (NSCLC) and assess its prognostic value for patients.Methods ASCL2 protein expression was detected by immunohistochemistry (IHC cohort) in 79 cases of squamous cell carcinoma (SCC) and 67 cases of adenocarcinoma (AC). Kaplan-Meier analysis and Cox regression analysis were performed to evaluate the prognostic significance of ASCL2. The same analyses were conducted in a cohort (n=790) from The Cancer Genome Atlas database (TCGA) to validate the expression pattern and prognostic value of ASCL2.Results ASCL2 expression levels were significantly increased in SCC compared with normal lung tissue (p