EXTRACTS OF INTERFERON-TREATED CELLS CAN INHIBIT RETICULOCYTE LYSATE PROTEIN-SYNTHESIS
EXTRACTS OF INTERFERON-TREATED CELLS CAN INHIBIT RETICULOCYTE LYSATE PROTEIN-SYNTHESIS
复制标题
DOI：
10.1016/s0006-291x(77)80173-3
复制
发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
FARRELL, PJ
中科院分区：
文献类型：
--
作者：
COOPER, JA;FARRELL, PJ
干扰素处理的[小鼠成纤维细胞]L929细胞的细胞质提取物在与双链RNA和ATP孵育时能够形成网状细胞裂解蛋白合成的抑制剂。这种抑制显然是通过甲硫基trnaf结合因子的磷酸化引起的，导致多肽链起始缺陷。
Cytoplasmic extracts of interferon-treated [mouse fibroblast] L929 cells are capable of forming an inhibitor of reticulocyte lysate protein synthesis when incubated with double stranded RNA and ATP. This inhibition apparently arises through phosphorylation of the methionyl-tRNAf binding factor, causing a defect in polypeptide chain initiation.