Rapid, membrane-initiated actions of 1,25 dihydroxyvitamin D: What are they and what do they mean?
Rapid, membrane-initiated actions of 1,25 dihydroxyvitamin D: What are they and what do they mean?
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DOI：
10.1093/jn/134.12.3215
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发表时间：
2004-12-01
影响因子：
4.2
通讯作者：
Fleet, JC
中科院分区：
文献类型：
--
作者：
Fleet, JC
维生素 D 是一种有条件必需的营养素，传统上被认为通过与维生素 D 受体 (VDR) 结合并通过直接 VDR-DNA 相互作用刺激基因转录，以代谢物 1,25-二羟基维生素 D [1,25(OH)(2) D] 的形式影响生理机能。然而，过去 15 年的研究表明，1,25(OH)(2) D 以及其他类固醇激素可以通过转录独立机制快速刺激离子通量并激活蛋白激酶。本综述总结了有关 1,25(OH)(2) D 快速作用的最新研究，并确定了该领域仍有待解答的问题。
Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions. However, over the past 15 y research has demonstrated that 1,25(OH)(2) D, as well as other steroid hormones, can rapidly stimulate ion fluxes and activate protein kinases by transcription-independent mechanisms. This review summarizes recent research on the rapid actions of 1,25(OH)(2) D and identifies questions that remain to be answered in this area.