Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
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深入了解翻译后修饰及其在塑造肿瘤微环境中的新作用
DOI：
10.1038/s41392-021-00825-8
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发表时间：
2021-12-20
影响因子：
39.3
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Li W;Li F;Zhang X;Lin HK;Xu C
越来越多的深度研究表明，肿瘤的发生和发展取决于基因突变和肿瘤异质性。肿瘤异质性最重要的表现是肿瘤微环境（TME）异质性的动态变化。这不仅取决于微环境中肿瘤细胞本身，在该环境中，浸润的免疫细胞和基质共同形成抗肿瘤和/或促肿瘤网络。 TME导致了新型的治疗干预措施，作为肿瘤床以外的地方。恶性癌细胞，肿瘤浸润免疫细胞，血管生成血管细胞，淋巴内皮细胞，与癌症相关的成纤维细胞细胞以及释放的因子，包括细胞内代谢产物，激素信号和炎症介质，均为癌症进展。蛋白质后翻译后修饰（PTM）通常被视为蛋白质破坏或营业额的降解机制，以维持生理稳态。基于定量转录组学，蛋白质组学和基于核酸酶的基因编辑的进展现在正在铺平探索PTM的全球方式。在这篇综述中，我们专注于PTM领域的最新发展，并推测其重要性是对TME调节的关键功能读数。大量信息已经出现，以证明在寻找常规疗法和制定全球治疗策略方面非常有用。
More and more in-depth studies have revealed that the occurrence and development of tumors depend on gene mutation and tumor heterogeneity. The most important manifestation of tumor heterogeneity is the dynamic change of tumor microenvironment (TME) heterogeneity. This depends not only on the tumor cells themselves in the microenvironment where the infiltrating immune cells and matrix together forming an antitumor and/or pro-tumor network. TME has resulted in novel therapeutic interventions as a place beyond tumor beds. The malignant cancer cells, tumor infiltrate immune cells, angiogenic vascular cells, lymphatic endothelial cells, cancer-associated fibroblastic cells, and the released factors including intracellular metabolites, hormonal signals and inflammatory mediators all contribute actively to cancer progression. Protein post-translational modification (PTM) is often regarded as a degradative mechanism in protein destruction or turnover to maintain physiological homeostasis. Advances in quantitative transcriptomics, proteomics, and nuclease-based gene editing are now paving the global ways for exploring PTMs. In this review, we focus on recent developments in the PTM area and speculate on their importance as a critical functional readout for the regulation of TME. A wealth of information has been emerging to prove useful in the search for conventional therapies and the development of global therapeutic strategies.
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影响因子：
--
作者：
Aldana-Masangkay GI;Sakamoto KM
通讯作者：
Sakamoto KM
影响因子：
16.6
作者：
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通讯作者：
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影响因子：
16
作者：
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作者：
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通讯作者：
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11.5
作者：
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通讯作者：
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