Association between Maximal Oxygen Uptake and the Heart Rate Corrected-QT Interval in Postmenopausal Overweight Women
Association between Maximal Oxygen Uptake and the Heart Rate Corrected-QT Interval in Postmenopausal Overweight Women
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DOI：
10.5551/jat.no927
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Tsuruta, Toshiyuki
中科院分区：
文献类型：
--
作者：
Michishita, Ryoma;Shono, Naoko;Tsuruta, Toshiyuki
背景提高有氧能力可以降低心血管疾病的发病率和死亡率。另一方面，心率校正的QT（QTc）间期延长与心律失常、心脏性猝死和冠状动脉疾病的风险增加有关。58.7 +/- 6.4岁，体重指数（BMI）：27.9 +/- 3.3]，有冠状动脉风险因素。在休息5分钟以上后，使用标准静息12导联ECG记录心电图（ECG）。根据Bazett公式自动计算QTc间期。在电动自行车功率计上进行多级分级次极量运动试验，以确定估计的最大摄氧量（（V）over dotO（2 max））。单相关分析显示QTc间期与HbA（1c）、空腹血糖、空腹胰岛素、BMI、腰围、血钾及冠心病危险因素数呈正相关，而与（V）在dot 0（2 max）上呈负相关。逐步多元回归分析显示QTc间期与HbA（1c）和（V）在dotO（2 max）上的强相关性（r（2）= 0.244，p < 0.0001）。在患有和不患有代谢综合征的患者中QTc间期与HbA 1c独立相关（r（2）= 0.318，P < 0.05; r（2）= 0.115，P < 0.05）。这些结果表明，有氧能力下降和葡萄糖耐受不良可能是QTc间期延长的独立危险因素，而与代谢综合征无关。
Background. Increased aerobic capacity can reduce the incidence of cardiovascular disease and the mortality rate. On the other hand, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of arrhythmias, cardiac sudden death and coronary artery disease.Aims: The association of the aerobic capacity and coronary risk factors with QTc interval was investigated in postmenopausal overweight women.Subjects and Methods: The subjects included 84 postmenopausal overweight women [age: 58.7 +/- 6.4 years, body mass index (BMI): 27.9 +/- 3.3] with coronary risk factors. Electrocardiogram (ECG) was recorded with a standard resting 12-lead ECG after more than 5 minutes of rest. The QTc interval was automatically calculated according to Bazett's formula. A multistage graded submaximal exercise test was performed on an electric bicycle ergometer to determine the estimated maximal oxygen uptake ((V) over dotO(2max)).Results: Single correlation analysis showed the QTc interval to be positively associated with hemoglobin A(1c) (HbA(1c)), fasting glucose, fasting insulin, BMI, waist circumference, serum potassium and the number of coronary risk factors, while negatively correlated with (V) over dotO(2max). Stepwise multiple regression analysis demonstrated the strong association of the QTc interval with HbA(1c) and (V) over dotO(2max) (r(2) = 0.244, p < 0.0001). In both patients with and without metabolic syndrome (n = 15, n = 69, respectively), the QTc interval was independently associated with the HbA(1c) (r(2) = 0.318, p < 0.05, r(2) = 0.115, P < 0.05, respectively).Conclusions: These results suggest that decreased aerobic capacity and glucose intolerance may be independent risk factors for a prolonged QTc interval, while demonstrating no relationship with metabolic syndrome.