An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification
An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification
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DOI：
10.3945/jn.112.158014
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发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Kiely, Mairead
中科院分区：
文献类型：
--
作者：
Black, Lucinda J.;Seamans, Kelly M.;Kiely, Mairead
食品强化是一种潜在有效的公共卫生策略，可增加维生素D摄入量和循环25-羟基维生素D [25（OH）D]浓度。我们更新了以前的系统性综述，以评估社区居民成人中强化食品对25（OH）D浓度影响的随机对照干预研究的现有证据。检索了奥维德MEDLINE、PubMed、CINAHL、Embase和科克伦对照试验中心，以查找在自由生活成人中使用维生素D强化食品的随机对照干预研究和循环25（OH）D数据。两名评审员独立筛选了441篇合格论文并提取了相关数据。使用随机效应模型对循环25（OH）D浓度的绝对平均变化进行荟萃分析。纳入了来自15篇出版物的16项研究，其中14项研究显示强化食品对25（OH）D浓度有显著影响。异源性高（P = 0.001）。
Food fortification is a potentially effective public health strategy to increase vitamin D intakes and circulating 25-hydroxyvitamin D [25(OH)D] concentrations. We updated a previous systematic review to evaluate current evidence from randomized controlled intervention studies in community-dwelling adults of the effect of fortified foods on 25(OH)D concentrations. Ovid MEDLINE, PubMed, CINAHL, Embase, and Cochrane Central Register of Controlled Trials were searched for randomized controlled intervention studies with vitamin D-fortified foods in free-living adults and data on circulating 25(OH)D. Two reviewers independently screened 441 papers for eligibility and extracted the relevant data. A meta-analysis of the absolute mean change in circulating 25(OH)D concentrations was conducted using a random effects model. Sixteen studies from 15 publications were included, of which 14 showed a significant effect of fortified foods on 25(OH)D concentrations. Heterogeneity was high (P =