ESTROGEN AND PROGESTIN RECEPTORS IN THE REPRODUCTIVE-TRACT OF MALE AND FEMALE PRIMATES
ESTROGEN AND PROGESTIN RECEPTORS IN THE REPRODUCTIVE-TRACT OF MALE AND FEMALE PRIMATES
复制标题
DOI：
10.1095/biolreprod42.1.11
复制
发表时间：
1990-01-01
影响因子：
3.6
通讯作者：
MCCLELLAN, MC
中科院分区：
文献类型：
--
作者：
BRENNER, RM;WEST, NB;MCCLELLAN, MC
借助雌激素和雌激素受体特异性单克隆抗体，我们研究了这些蛋白质在雄性和雌性猕猴生殖道中的细胞定位。从我们对这些新试剂的研究中得到了两个惊人的发现。首先，这些受体仅在细胞核中可检测到，与激素治疗无关，第二，当上皮细胞经历各种雌激素或孕激素依赖性事件时，它们通常在基质细胞中可检测到，但在上皮细胞中不可检测到。后一个观察结果使我们得出结论，基质细胞上皮细胞的相互作用可能发挥以前不受重视的作用，在灵长类动物生殖道的激素控制。我们将对促使我们得出这一结论的证据进行审查。
With the aid of monoclonal antibodies specific to the estrogen and progestin receptors, we have examined the cellular localization of these proteins in the reproductive tract of male and female macaques. Two striking findings have resulted from our work with these new reagents. First, these receptors are detectable only in cell nuclei, regardless of hormonal treatment, and second, they are often detectable in stromal, but not epithelial cells when the epithelial cells undergo various estrogen or progestin-dependent events. The latter observation has led us to conclude that stromal cell-epithelial cell interactions may play previously unappreciated roles in the hormonal control of the primate reproductive tract. The lines of evidence that have drawn us to this conclusion will be reviewed.