Cyclonerane Derivatives from the Algicolous Endophytic Fungus Trichoderma asperellum A-YMD-9-2
Cyclonerane Derivatives from the Algicolous Endophytic Fungus Trichoderma asperellum A-YMD-9-2
复制标题
来自藻生内生真菌木霉 A-YMD-9-2 的环旋花烷衍生物
DOI：
10.3390/md17050252
复制
发表时间：
2019-05-01
期刊：
影响因子：
5.4
通讯作者：
Ji, Nai-Yun
中科院分区：
文献类型：
--
作者：
Song, Yin-Ping;Miao, Feng-Ping;Ji, Nai-Yun
从从海洋红藻中分离得到的内生真菌Gricderasperellum A-ymd-9-2的培养物(Tricderasperellum A-ymd-9-2)中分离得到7个未见报道的环烷衍生物，分别为3，7，11-三羟基-10-酮、3，7，10-四醇、3，7，11-三醇、11，12，15-三环-3，7-三醇、11，12，15-三环-3，7-三醇、7，10S-环氧环-3，15-二醇和(10Z)-15-乙氧基-10-环烯-3，7-二醇。通过1D/2D核磁共振、MS和IR等波谱技术确定了以前未见报道的化合物的结构。这些新的环丙烷衍生物的分离极大地增加了不寻常的环丙烷倍半萜的结构多样性，并且几个分离株对一些海洋浮游植物具有很强的抑制作用。
Seven previously unreported cyclonerane derivatives, namely, 3,7,11-trihydroxycycloneran-10-one, cycloneran-3,7,10,11-tetraol, cycloneran-3,7,11-triol, 11,12,15-trinorcycloneran-3,7,10-triol, 7,10S-epoxycycloneran-3,15-diol, 7,10R-epoxycycloneran-3,15-diol, and (10Z)-15-acetoxy-10-cycloneren-3,7-diol, were isolated in addition to the known (10Z)-cyclonerotriol, (10E)-cyclonerotriol, catenioblin C, and chokol E from the culture of Trichoderma asperellum A-YMD-9-2, an endophytic fungus obtained from the marine red alga Gracilaria verrucosa. The structures of previously unreported compounds were established by spectroscopic techniques, including 1D/2D NMR, MS, and IR. The isolation of these new cyclonerane derivatives greatly adds to the structural diversity of unusual cyclonerane sesquiterpenes, and several isolates exhibit potent inhibition against some marine phytoplankton species.