Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications.
Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications.
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DOI：
10.3390/s151229783
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发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Hoorfar M
中科院分区：
文献类型：
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作者：
Luka G;Ahmadi A;Najjaran H;Alocilja E;DeRosa M;Wolthers K;Malki A;Aziz H;Althani A;Hoorfar M
生物传感器可以被定义为一种紧凑的分析装置或单元，其包含固定在物理化学换能器上的生物或生物衍生的敏感识别元件，以测量一种或多种分析物。另一方面，微流体系统提供通量处理，增强用于控制流动条件的输送，增加不同试剂的混合速率，减少样品和试剂体积（低至纳升），增加检测灵敏度，并利用相同的平台进行样品制备和检测。鉴于这些优点，微流体和生物传感器技术的集成提供了将化学和生物组分合并到单个平台中的能力，并为未来的生物传感应用提供了新的机会，包括便携性，一次性，实时检测，前所未有的准确性，以及在单个设备中同时分析不同的分析物。本文综述了微流体生物传感领域的研究进展。该综述还介绍了从文献中提取的例子，以展示合并微流体和生物传感技术的优势，并说明这种集成在未来生物传感的生物工程，生物医学研究，即时诊断，环境监测和精准农业的新兴领域的多功能性。
A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. Microfluidic systems, on the other hand, provide throughput processing, enhance transport for controlling the flow conditions, increase the mixing rate of different reagents, reduce sample and reagents volume (down to nanoliter), increase sensitivity of detection, and utilize the same platform for both sample preparation and detection. In view of these advantages, the integration of microfluidic and biosensor technologies provides the ability to merge chemical and biological components into a single platform and offers new opportunities for future biosensing applications including portability, disposability, real-time detection, unprecedented accuracies, and simultaneous analysis of different analytes in a single device. This review aims at representing advances and achievements in the field of microfluidic-based biosensing. The review also presents examples extracted from the literature to demonstrate the advantages of merging microfluidic and biosensing technologies and illustrate the versatility that such integration promises in the future biosensing for emerging areas of biological engineering, biomedical studies, point-of-care diagnostics, environmental monitoring, and precision agriculture.