25-Hydroxyvitamin D Concentration and Sleep Duration and Continuity: Multi-Ethnic Study of Atherosclerosis
25-Hydroxyvitamin D Concentration and Sleep Duration and Continuity: Multi-Ethnic Study of Atherosclerosis
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DOI：
10.5665/sleep.4914
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发表时间：
2015-08-01
期刊：
影响因子：
5.6
通讯作者：
Redline, Susan
中科院分区：
文献类型：
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作者：
Bertisch, Suzanne M.;Sillau, Stefan;Redline, Susan
研究目标：确定25-羟基维生素D(25(OH)D)浓度与睡眠连续性、睡眠质量和睡眠症状的关系，并探索种族/民族差异。设计：横断面研究。背景：动脉粥样硬化(MESA)多民族研究。参与者：1,721名成年人。测量和结果：通过多导睡眠图、活动图和问卷测量睡眠结果。血清25(OH)D浓度以临床阈值(<20，20~29，<30 ng/m L)连续表示。通过线性回归，我们确定了25(OH)D浓度与睡眠时间、效率和症状之间的关系，并评估了种族/民族差异。平均年龄为68.2+/-9.1岁，其中37.2%是白人，27.7%是非裔美国人，11.9%是华裔美国人，23.2%是西班牙裔。25(OH)D平均浓度为25.4+/-10.5 ng/mL。25(OH)D缺乏的参与者睡眠时间最短，睡眠效率最低，嗜睡评分最高。在调整了人口统计、肥胖和健康习惯后，睡眠不足的人比睡眠充足的人平均少睡13.0分钟(95%可信区间，-22.8，-3.2)。种族/民族分层分析表明，非洲裔美国人的相关性最强，他们的调整睡眠时间在不足的人比充足的人少25.6+/-11.7min(P=0.04)，在华裔美国人中，调整后的呼吸暂停低通气指数(AHI)在不足的人比足够的人高7.5+/-3.3事件/小时。结论：总体而言，25-羟基维生素D(25(OH)D)浓度与睡眠特征之间的关联不大。然而，种族分层分析表明，25(OH)D浓度与睡眠特征之间的关联因种族/民族而异。在非裔美国人中，维生素D缺乏与睡眠时间短的相关性最强，在华裔美国人中，维生素D缺乏与呼吸暂停低通气指数升高的相关性最强，这表明种族/民族可能会改变这些相关性。
Study Objectives: To determine the associations of 25-hydroxyvitamin D (25(OH)D) concentration with sleep continuity, quality, and symptoms, and to explore race/ethnic variation.Design: Cross-sectional study.Setting: Multi-Ethnic Study of Atherosclerosis (MESA).Participants: There were 1,721 adults.Measurements and Results: Sleep outcomes were measured by polysomnography, actigraphy, and questionnaires. Serum 25(OH)D concentration was expressed by clinical thresholds (< 20, 20-29, >= 30 ng/mL) and continuously. Using linear regression, we determined the associations between 25(OH)D concentration and sleep duration, efficiency, and symptoms, and assessed race/ethnic variation. Mean age was 68.2 +/- 9.1 y, and 37.2% were white, 27.7% African American, 11.9% Chinese Americans, and 23.2% Hispanic. Mean 25(OH)D concentration was 25.4 +/- 10.5 ng/mL. 25(OH)D deficient participants had the shortest sleep duration, lowest sleep efficiency, and highest sleepiness scores. After adjusting for demographics, obesity, and health habits, deficient individuals slept an average of 13.0 min (95% confidence interval, -22.8, -3.2) shorter than sufficient individuals. Race/ethnic-stratified analyses indicated that the strongest associations were in African Americans, in whom adjusted sleep duration was 25.6 +/- 11.7 min shorter in deficient versus sufficient individuals (P = 0.04), and in Chinese Americans, adjusted apnea-hypopnea index (AHI) was 7.5 +/- 3.3 events/h higher in deficient versus sufficient individuals.Conclusion: Overall, there were modest associations between 25-hydroxyvitamin D (25(OH)D) concentration and sleep traits. However, race-stratified analyses suggested the association between 25(OH)D concentration and sleep traits varied by race/ethnicity. Vitamin D deficiency was most strongly associated with short sleep duration in African Americans and with elevated apnea-hypopnea index in Chinese Americans, suggesting that race/ethnicity may modify these associations.