1H Magnetic resonance spectroscopy in dementia
1H Magnetic resonance spectroscopy in dementia
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DOI：
10.1259/bjr/60346217
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Kantarci, K.
中科院分区：
文献类型：
--
作者：
Kantarci, K.
目前的数据支持的概念，H-1磁共振波谱（H-1 MRS）可能成为一个辅助临床评价鉴别诊断痴呆症的未来。H-1 MRS在监测痴呆症疾病进展方面的价值预计将在寻求群体效应的领域，例如监测药物试验中治疗的有效性。在轻度认知功能障碍和症状前阿尔茨海默病患者中，肌醇与肌酸（ml/Cr）和胆碱与肌酸（Cho/Cr）的比值升高，神经元完整性标志物N-乙酰天冬氨酸与肌酸（NAA/Cr）的比值降低，表明H-1 MRS在预测未来痴呆的发展和监测早期疾病进展以进行预防性治疗方面也可能有价值。然而，将体内H-1 MRS作为痴呆鉴别诊断和进展的标志物的研究仅限于临床证实的队列，仍有待尸检时的组织病理学验证。总的来说，MRS是一种很有前途的研究技术，在老龄化和痴呆症在这个时候。然而，随着该领域的技术进步，MRS在老龄化和痴呆症中的潜在临床应用正在增长。
Present data support the concept that H-1 magnetic resonance spectroscopy (H-1 MRS) may become an adjunct to clinical evaluation for differential diagnosis of dementia in the future. The value of H-1 MRS in monitoring the disease progression in dementia is expected to be in areas where group effects are sought such as monitoring effectiveness of therapies in drug trials. Elevation of myoinositol to creatine (ml/Cr) and choline to creatine (Cho/Cr) and reduction in the neuronal integrity marker N-acetylaspartate to creatine (NAA/Cr) levels in individuals with mild cognitive impairment and pre-symptomatic Alzheimer's disease suggests that H-1 MRS may also be valuable in predicting future development of dementia and monitoring early disease progression for preventive therapies. Investigations of in vivo H-1 MRS as a marker for differential diagnosis and progression of dementia, however, has been limited to clinically confirmed cohorts and remains to be validated by histopathology at autopsy. Overall, MRS is a promising investigational technique in ageing and dementia at this time. The potential clinical application of MRS in ageing and dementia, however, is growing with technical advances in the field.