Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
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DOI：
10.1006/geno.1996.0518
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发表时间：
1996-10-01
期刊：
影响因子：
4.4
通讯作者：
Marsh, DG
中科院分区：
文献类型：
--
作者：
Barnes, KC;Neely, JD;Marsh, DG
为了鉴定可能与特应性哮喘相关的基因，我们分析了染色体12 q15-q24.1中与哮喘和总血清IgE浓度相关的标记物。来自29个多重非洲-加勒比家庭的345个全同胞对和219个半同胞对中的10个标记物的同胞对分析提供了与该地区哮喘和血清总IgE相关的证据。在这些位点的某些等位基因表现出与哮喘和高IgE的传播不平衡的显着证据。使用这些标记和11个额外的标记，总IgE的连锁证据12 q也发现在12个高加索阿米什kinasia（24个核心家庭）的同胞对和传输不平衡分析。这些发现表明，12 q15-q24.1区域可能包含控制哮喘的基因和相关的“高总IgE”性状。(C)出版社：Academic Press，Inc.
To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum IgE concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to this region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of transmission disequilibrium with both asthma and high IgE. Using 6 of these markers and 11 additional markers, evidence for linkage of total IgE to 12q was also found in 12 Caucasian Amish kindreds (24 nuclear families) by both sib-pair and transmission disequilibrium analyses. These findings suggest that the 12q15-q24.1 region may contain a gene(s) controlling asthma and the associated ''high total IgE'' trait. (C) 1996 Academic Press, Inc.