Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects
Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects
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DOI：
10.1093/aje/kwp226
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发表时间：
2009-10-15
影响因子：
5
通讯作者：
Reefhuis, Jennita
中科院分区：
文献类型：
--
作者：
Cogswell, Mary E.;Bitsko, Rebecca H.;Reefhuis, Jennita
为了评估在美国10个中心进行的基于人群的出生缺陷病例对照研究中对照组的代表性，研究人员将1997-2003年与选定对照组（n = 6，681）和对照组参与者（n = 4，395）相关的出生证明数据与其基础人群（n = 2，468，697）进行了比较。研究人员分析了人口特征的差异（例如，出生时体重≥ 2，500克的百分比）。与他们的基础人群相比，对照组参与者在母亲或父亲年龄、既往活产、母亲吸烟或糖尿病的分布方面没有差异，但在其他母亲（即，种族/民族、教育、接受产前护理）和婴儿（即，出生体重、胎龄和多个）特征。产妇，但不是婴儿，特征的分布差异与选定的控制参与。基础人群与对照人群的婴儿特征绝对差异< 1.3个百分点。与从电子出生证明中选择对照的中心相比，从医院选择对照的中心的婴儿特征差异更大。这些研究结果表明，在全国出生缺陷预防研究的控制参与者一般是他们的基础人群的代表。以医院为基础的对照选择可能会稍微低估某些不良出生结局影响的婴儿。
To evaluate the representativeness of controls in an ongoing, population-based, case-control study of birth defects in 10 centers across the United States, researchers compared 1997-2003 birth certificate data linked to selected controls (n = 6,681) and control participants (n = 4,395) with those from their base populations (n = 2,468,697). Researchers analyzed differences in population characteristics (e.g., percentage of births at >= 2,500 g) for each group. Compared with their base populations, control participants did not differ in distributions of maternal or paternal age, previous livebirths, maternal smoking, or diabetes, but they did differ in other maternal (i.e., race/ethnicity, education, entry into prenatal care) and infant (i.e., birth weight, gestational age, and plurality) characteristics. Differences in distributions of maternal, but not infant, characteristics were associated with participation by selected controls. Absolute differences in infant characteristics for the base population versus control participants were < 1.3 percentage points. Differences in infant characteristics were greater at centers that selected controls from hospitals compared with centers that selected controls from electronic birth certificates. These findings suggest that control participants in the National Birth Defects Prevention Study generally are representative of their base populations. Hospital-based control selection may slightly underascertain infants affected by certain adverse birth outcomes.