Pathogenic conversion of Foxp3+ T cells into Th17 cells: is this also the case for multiple sclerosis?
Pathogenic conversion of Foxp3+ T cells into Th17 cells: is this also the case for multiple sclerosis?
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Foxp3 T 细胞致病性转化为 Th17 细胞：多发性硬化症也是如此吗？
DOI：
10.1111/cen3.12114
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Saito M.
中科院分区：
文献类型：
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作者：
Saito M;Tanaka R;Fujii H;Kodama A;Takahashi Y;Matsuzaki T;Takashima H;Tanaka Y.;Saito M.
多发性硬化症（MS）是一种影响大脑和脊髓的中枢神经系统炎症性疾病。T辅助17 （Th17）细胞在MS和其他先前归因于Th1细胞的自身免疫性疾病的发病机制中发挥了关键作用。发表在《自然医学》杂志上的一项新研究表明，CD25lowFoxP3+CD4+T细胞可以在体内分化为Th17细胞，这些细胞在自身免疫性关节炎的发病机制中发挥重要作用。考虑到自身反应性T细胞，特别是Th17细胞在MS中的作用，这种源自FoxP3+T细胞的exFoxP3 Th17细胞也可能能够控制MS的发生和进展。
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that affects the brain and spinal cord. T helper 17 (Th17) cells have emerged as a key player in the pathogenesis of MS and other autoimmune disorders previously attributed to Th1 cells. New research published inNature Medicinehas shown that CD25lowFoxP3+CD4+T cells can differentiate into Th17 cellsin vivo, and that these cells play an important role in the pathogenesis of autoimmune arthritis. Considering the role of autoreactive T cells particularly Th17 cells in MS, such exFoxP3 Th17 cells derived from FoxP3+T cells might also be able to control the initiation and progression of MS.