MORPHINE ANALGESIA IN THE FORMALIN TEST - EVIDENCE FOR FOREBRAIN AND MIDBRAIN SITES OF ACTION
MORPHINE ANALGESIA IN THE FORMALIN TEST - EVIDENCE FOR FOREBRAIN AND MIDBRAIN SITES OF ACTION
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DOI：
10.1016/0306-4522(94)90023-x
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发表时间：
1994-11-01
期刊：
影响因子：
3.3
通讯作者：
FRANKLIN, KBJ
中科院分区：
文献类型：
--
作者：
MANNING, BH;MORGAN, MJ;FRANKLIN, KBJ
进行了一项绘图研究，以确定大鼠大脑中吗啡在福尔马林试验中发挥镇痛作用的位置，福尔马林试验是与组织损伤相关的长期疼痛的动物模型。将单剂量（5 nmol）吗啡双侧显微注射到整个中脑和前脑的广泛大脑区域。下丘脑后区、导水管周围灰质和腹侧被盖区产生强镇痛作用。其他引起镇痛的部位是伏隔核以及红核后区和尾壳核的一些部位。导水管周围灰质或伏隔核的镇痛伴随着运动活动的减少和僵直，而下丘脑后区或腹侧被盖的镇痛则伴随着运动活动和站立的明显增加。吗啡进入各个丘脑核团没有作用。这些结果表明，福尔马林试验中吗啡的主要作用部位可能是下丘脑后区和导水管周围灰质，还有被盖多巴胺细胞支配的区域的额外贡献。
A mapping study was performed to determine where in the rat brain morphine acts to produce analgesia in the formalin test, which is an animal model of prolonged pain associated with tissue injury. A single dose (5 nmol) of morphine was bilaterally microinjected into a wide range of brain areas throughout the midbrain and forebrain. Strong analgesia was elicited from the posterior hypothalamic area, the periaqueductal gray and ventral tegmental area. Other sites from which analgesia was elicited were the nucleus accumbens and a few sites in the retrorubral field and caudate-putamen, Analgesia from the periaqueductal gray or nucleus accumbens was accompanied by decreased locomotor activity and catalepsy, whereas analgesia from the posterior hypothalamic area or ventral tegmentum was accompanied by a noticeable increase in locomotor activity and rearing. Morphine into various thalamic nuclei had no effect.These results indicate that the primary sites of action of morphine in the formalin test are probably the posterior hypothalamic area and periaqueductal gray, with an additional contribution from regions innervated by tegmental dopamine cells.