The Roles of SIRT1 in Cancer.
The Roles of SIRT1 in Cancer.
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DOI：
10.1177/1947601912475079
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发表时间：
2013-03-01
期刊：
影响因子：
--
通讯作者：
Fang, Deyu
中科院分区：
文献类型：
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作者：
Lin, Zhenghong;Fang, Deyu
Sirtuin家族已成为多种生理和病理事件的重要调节者，包括寿命延长、神经退化、年龄相关疾病、肥胖、心脏病、炎症和癌症。在哺乳动物中，sirtuin家族有7个成员(SIRT1-SIRT7)，SIRT1的功能在过去的十年中得到了广泛的研究。SIRT1可以去乙酰化组蛋白和一些非组蛋白底物，这些底物参与了多种信号通路。大量研究表明，SIRT1既可以作为肿瘤抑制因子，也可以作为肿瘤促进剂，这取决于它在特定信号通路或特定癌症中的靶点。本文重点介绍了SIRT1参与肿瘤发生的主要途径。
The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in the past decade. SIRT1 can deacetylate histones and a number of nonhistone substrates, which are involved in multiple signaling pathways. Numerous studies have suggested that SIRT1 could act as either a tumor suppressor or tumor promoter depending on its targets in specific signaling pathways or in specific cancers. This review highlights the major pathways regulated by SIRT1 involved in tumorigenesis.