Achieving Independent Control over Surface and Bulk Fluid Flows in Microchambers
Achieving Independent Control over Surface and Bulk Fluid Flows in Microchambers
复制标题
实现微室中表面和本体流体流动的独立控制
DOI：
10.1021/acsami.0c21291
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发表时间：
2021
影响因子：
9.5
通讯作者：
Sen, Ayusman
中科院分区：
文献类型：
--
作者：
Tansi, Benjamin M.;Manna, Raj Kumar;Shklyaev, Oleg E.;Peris, Matthew L.;Balazs, Anna C.;Sen, Ayusman
为了充分发挥微流控平台作为有用诊断工具的潜力，这些设备必须足够便携，以便在医疗点以及偏远和资源贫乏的地方发挥作用。使用建模和实验，在这里我们开发了一个独立的流体装置，由光驱动，无需外部电动或机械泵即可运行。光在溶液中引发光化学反应；从反应中释放的化学能被转化为周围流体的自发运动。产生的流动由两种同时发生的机制驱动：控制大块流体运动的溶质浮力和调节腔室底部附近运动的扩散渗透。因此，体流和表面流体流动可以彼此独立地定向。我们证明，这种特殊程度的时空控制为不同大小的粒子在腔室内以相反方向自主传输提供了一种新方法。因此，一种设备既可以分离颗粒，又可以将它们驱动到不同的位置进行进一步的处理或分析。这一特性对于分析含有多种污染物或致病因子的流体特别有用。由于该系统依赖于由便携式小型光源启动的固有流体动力学相互作用，因此该设备为下一代功能性流体平台提供了所需的移动性水平。
To fully realize the potential of microfluidic platforms as useful diagnostic tools, the devices must be sufficiently portable that they function at the point-of-care, as well as remote and resource-poor locations. Using both modeling and experiments, here we develop a standalone fluidic device that is driven by light and operates without the need for external electrical or mechanical pumps. The light initiates a photochemical reaction in the solution; the release of chemical energy from the reaction is transduced into the spontaneous motion of the surrounding fluid. The generated flow is driven by two simultaneously occurring mechanisms: solutal buoyancy that controls the motion of the bulk fluid and diffusioosmosis that regulates motion near the bottom of the chamber. Consequently, the bulk and surface fluid flows can be directed independently of one another. We demonstrate that this exceptional degree of spatiotemporal control provides a new method for autonomously transporting different-sized particles in opposite directions within the chamber. Thus, one device can be used to both separate the particles and drive them to different locations for further processing or analysis. This property is particularly useful for analyzing fluids that contain multiple contaminants or disease agents. Because this system relies on intrinsic hydrodynamic interactions initiated by a portable, small-scale source of light, the device provides the desired level of mobility vital for the next generation of functional fluidic platforms.