Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas.
Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas.
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DOI：
10.1016/0014-2999(86)90651-5
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发表时间：
1986-01
影响因子：
5
通讯作者：
R. Rapoport;R. Winquist;E. Baskin;E. Faison;S. Waldman;F. Murad
中科院分区：
文献类型：
--
作者：
R. Rapoport;R. Winquist;E. Baskin;E. Faison;S. Waldman;F. Murad
本实验观察了心房肽Ⅰ和Ⅱ对大鼠和家兔胸主动脉的舒张作用和环鸟苷酸（cGMP）水平的影响。心房肽素I在引起大鼠和兔心房肌松弛方面的效力分别比心房肽素II低2倍和100倍。心房肽升高的环GMP水平一般与放松量相关。这些结果表明，血管扩张的档案，并推测，心房利钠因子受体，不同的血管和物种之间的变化。
The effects of atriopeptins I and II on relaxation and cyclic GMP levels were studied on rat and rabbit aortas. Atriopeptin I was 2- and 100-fold less potent than atriopeptin II in causing relaxation of rat and rabbit aortas, respectively. The atriopeptin-elevated cyclic GMP levels generally correlated with the amount of relaxation. These results demonstrate that the vasodilator profile and, presumably, the receptor for atrial natriuretic factor, varies among different blood vessels and species.