Corneal tissue levels of topically applied ofloxacin
Corneal tissue levels of topically applied ofloxacin
复制标题
局部应用氧氟沙星的角膜组织水平
DOI：
10.1016/s0886-3350(97)80251-9
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发表时间：
1997
影响因子：
2.8
通讯作者：
S. Johns
中科院分区：
文献类型：
--
作者：
F. Price;W. E. Whitson;J. Gonzales;S. Johns
目的：评估暴露于各种给药方案和应用methods.Setting：角膜顾问的印第安纳州，印第安纳波利斯，印第安纳州，美国的人角膜组织中的氧氟沙星（Ocuflox®）的水平。方法：从计划进行穿透性角膜移植术（PKP）的人中招募40例符合纳入标准的患者。根据给药方案和给药方法，将患者分为两个研究组，每组20例。SAS GLM（一般线性模型）程序被用来测试的差异，平均Ocuflox组织浓度研究组之间的相互作用的术前诊断，环锯大小，给药方案，和角膜integrity.Results：角膜组织浓度的Ocuflox升高显着通过不同的药物应用方法和给药方案前PKP。每15分钟接受一次药物治疗4小时的眼睛比手术前24小时接受6次药物治疗的眼睛的Ocuflox水平显著更高。Ocuflox浓度超过了MIC 90（最低抑菌浓度）的主要眼部病原体在基本上所有的角膜samples studied.Conclusion：Ocuflox渗透改善管理，在一个受控的设置在15分钟的间隔超过4小时。该药物在角膜和房水中提供了高组织水平，再加上其广泛的抗菌覆盖范围，应该使其成为预防性治疗的良好选择。
Purpose:To evaluate the levels of ofloxacin (Ocuflox®) in human corneal tissue in patients exposed to various dosing regimens and application methods.Setting:Corneal Consultants of Indiana, Indianapolis, Indiana, USA.Methods:Forty patients meeting inclusion criteria were recruited from persons scheduled to have penetrating keratoplasty (PKP). Patients were placed into one of two study groups of 20 each based on dosing regimen and application method. The SAS GLM (General Linear Models) procedure was used to test for differences in mean Ocuflox tissue concentration among study groups and for interaction effects of preoperative diagnosis, trephine size, dosing regimen, and corneal integrity.Results:Corneal tissue concentrations of Ocuflox were elevated significantly by varying drug application methods and dosing schedules before PKP. Eyes receiving medication every 15 minutes for 4 hours had significantly higher levels of Ocuflox than those receiving the drug in six doses over 24 hours before surgery. Ocuflox concentrations exceeded the MIC 90 (minimum inhibitory concentration) for key ocular pathogens in essentially all cornea specimens studied.Conclusion:Ocuflox penetration was improved by administering it in a controlled setting at 15 minute intervals over 4 hours. The drug provided high tissue levels in both the cornea and aqueous humor, which together with its broad range of antibacterial coverage, should make it a good choice for prophylactic treatment.