AUTORADIOGRAPHIC EXAMINATION OF CORTICO-CORTICAL AND SUB-CORTICAL PROJECTIONS OF THE MEDIODORSAL-PROJECTION (PREFRONTAL) CORTEX IN THE RAT
AUTORADIOGRAPHIC EXAMINATION OF CORTICO-CORTICAL AND SUB-CORTICAL PROJECTIONS OF THE MEDIODORSAL-PROJECTION (PREFRONTAL) CORTEX IN THE RAT
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DOI：
10.1002/cne.901840104
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
BECKSTEAD, RM
中科院分区：
文献类型：
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作者：
BECKSTEAD, RM
在大鼠丘脑背内侧核投射皮质（MD投射皮质）的不同部位微电泳注射~ 3 H-脯氨酸-亮氨酸后，用放射自显影技术重新观察了MD投射皮质的传出联系。与以前的负面研究结果相反，这些实验揭示了一个系统的广泛的皮质投射，并表明，不同地区的MD投射皮质有独特的模式，在他们的皮质和皮质下的预测。Brodmann 32区的细胞将轴突发送到压后皮质、29 d区、外嗅皮质和内嗅皮质以及前下托。24区的膝上区和更靠后的区域都投射到压后皮质和29 d区，但只有后部还投射到内嗅区和前下托。来自沟MD投射皮质的轴突的皮质目标主要是梨状皮质的前部，并且对于沟皮质的后外侧部分（岛区），是压后区、外侧内嗅区和前下托。虽然MD投射皮质的内侧和沟部相互投射，但内侧至沟部的投射通常比其相互的投射更密集。早期的研究结果，如中线丘脑核，下丘脑和旁正中中脑被盖的边缘系统附属的皮质下结构的预测得到证实，似乎主要起源于32区和岛叶部分的沟皮质。皮质丘脑投射到MD在一般情况下，从MD内的各个亚核团的丘脑皮质投射中看到的组织往复。先前未记录的投射主要表现为从内侧皮质的32区和沟皮质的岛状部分到杏仁外侧核和基底核、外侧隔核的内侧部分、外侧缰核和嗅结节的深层;外侧缰核的内侧部分接受来自32区和24区的投射。投射到顶盖前区和上级丘似乎起源于内侧MD投射皮质的所有部分，但当注射区域24的后部时，其密度明显增加。这种皮质-顶盖投影的分布显示出一种高度特征性的结构，其中高颗粒浓度的区域包围着低颗粒浓度的区域。
The efferent connections of the cortex projected upon by the mediodorsal thalamic nucleus (MD-projection cortex) were re-examined autoradiographically in the rat following microelectrophoretic injection of 3H-proline-leucine into different parts of the medial and sulcal MD-projection cortex. Contrary to previous negative findings, these experiments revealed a system of extensive corticocortical projections and indicated that different areas of the MD-projection cortex have distinctive patterns in both their corticocortical and subcortical projections. Cells of Brodmann''s area 32 send axons to the retrosplenial cortex, area 29d, the peri- and entorhinal cortices, and the presubiculum. Both supragenual and more posterior regions of area 24 project to the retrosplenial cortex and area 29d, but only the posterior portion projects additionally to the entorhinal area and presubiculum. The cortical targets of axons from the sulcal MD-projection cortex are mainly the anterior part of the piriform cortex and, for the posterolateral part of the sulcal cortex (insular area), the retrosplenial area, lateral entorhinal area and presubiculum. While the medial and sulcal divisions of the MD-projection cortex project upon one another, the medial-to-sulcal projection is in general denser than its reciprocal. Earlier findings of projections to subcortical structures affiliated with the limbic system such as midline thalamic nuclei, hypothalamus and paramedian mesencephalic tegmentum are confirmed, and appear to originate primarily in area 32 and the insular part of the sulcal cortex. The corticothalamic projection to MD in general terms reciprocates the organization seen in the thalamocortical projection from the various subnuclei within MD. Previously undocumented projections are demonstrated mainly from area 32 of the medial cortex and the insular part of the sulcal cortex to the lateral and basal amygdaloid nuclei, the medial part of the lateral septal nucleus, the nucleus accumbens, and the deep layers of the olfactory tubercle; the medial part of the lateral habenular nucleus receives a projection from areas 32 and 24. Projections to the pretectal area and superior colliculus appear to originate from all parts of the medial MD-projection cortex, but are markedly denser when the posterior part of area 24 is injected. The distribution of this corticotectal projection shows a highly characteristic configuration in which areas of high grain concentration surround areas of lower grain concentration.