Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma.
Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma.
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使用阵列比较基因组杂交（ACGH）对浆膜淋巴瘤的基因组分析：揭示了具有弥漫性大B细胞淋巴瘤的显着重叠基因组病变。
DOI：
10.1186/1756-8722-2-47
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发表时间：
2009-11-12
影响因子：
28.5
通讯作者：
Lau CC
中科院分区：
文献类型：
--
作者：
Chang CC;Zhou X;Taylor JJ;Huang WT;Ren X;Monzon F;Feng Y;Rao PH;Lu XY;Fabio F;Hilsenbeck S;Creighton CJ;Jaffe ES;Lau CC
浆母细胞淋巴瘤（PL）是弥漫性大B细胞淋巴瘤（DLBCL）的一个亚型。研究表明，PL形态的肿瘤代表了一组具有对应于不同实体的临床病理学特征的肿瘤，包括与浆细胞骨髓瘤（PCM）相关的髓外浆细胞骨髓瘤。本研究的目的是利用基于阵列的比较基因组杂交技术，评估PL、DLBCL（AIDS相关和非AIDS相关）和PCM之间的遗传相似性和差异性。对PL基因组数据的检查显示，最常见的节段性增加（> 40%）包括：1p36.11-1p36.33、1p34.1-1p36.13、1q21.1-1q23.1、7q11.2-7q11.23、11 q12 -11q13.2和22q12.2-22q13.3。这与DLBCL（艾滋病相关和非艾滋病相关）病例中高频发生的节段性增益相关。有一些节段性增益和一些节段性损失发生在PL，但不是在其他类型的淋巴瘤，这表明这些病灶可能含有基因负责这种淋巴瘤的分化。此外，一些节段性增益和一些节段性损失仅发生在PL和AIDS相关DLBCL中，这表明这些病灶可能与HIV感染相关。此外，一些节段性增益和一些节段性丢失仅发生在PL和PCM，这表明这些病变可能与浆细胞分化有关。据我们所知，目前的研究代表了PL的第一个基因组探索。与PCM相比，PL的基因组畸变模式似乎更类似于DLBCL（AIDS相关或非AIDS相关）。我们的研究结果表明，PL可能仍然是最好的分类为DLBCL的亚型，至少在基因组水平。
Plasmablastic lymphoma (PL) is a subtype of diffuse large B-cell lymphoma (DLBCL). Studies have suggested that tumors with PL morphology represent a group of neoplasms with clinopathologic characteristics corresponding to different entities including extramedullary plasmablastic tumors associated with plasma cell myeloma (PCM). The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization. Examination of genomic data in PL revealed that the most frequent segmental gain (> 40%) include: 1p36.11-1p36.33, 1p34.1-1p36.13, 1q21.1-1q23.1, 7q11.2-7q11.23, 11q12-11q13.2 and 22q12.2-22q13.3. This correlated with segmental gains occurring in high frequency in DLBCL (AIDS-related and non AIDS-related) cases. There were some segmental gains and some segmental loss that occurred in PL but not in the other types of lymphoma suggesting that these foci may contain genes responsible for the differentiation of this lymphoma. Additionally, some segmental gains and some segmental loss occurred only in PL and AIDS associated DLBCL suggesting that these foci may be associated with HIV infection. Furthermore, some segmental gains and some segmental loss occurred only in PL and PCM suggesting that these lesions may be related to plasmacytic differentiation. To the best of our knowledge, the current study represents the first genomic exploration of PL. The genomic aberration pattern of PL appears to be more similar to that of DLBCL (AIDS-related or non AIDS-related) than to PCM. Our findings suggest that PL may remain best classified as a subtype of DLBCL at least at the genome level.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.8
作者：
Man TK;Lu XY;Jaeweon K;Perlaky L;Harris CP;Shah S;Ladanyi M;Gorlick R;Lau CC;Rao PH
通讯作者：
Rao PH
影响因子：
7.5
作者：
Monzon, Federico A.;Hagenkord, Jill M.;Dhir, Rajiv
通讯作者：
Dhir, Rajiv
影响因子：
6.5
作者：
Gaidano, G;Cerri, M;Carbone, A
通讯作者：
Carbone, A
影响因子：
4.8
作者：
De Smaele, Enrico;Fragomeli, Caterina;Gulino, Alberto
通讯作者：
Gulino, Alberto