Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris
Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris
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DOI：
10.1016/j.jaad.2006.10.005
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发表时间：
2007-03-01
影响因子：
13.8
通讯作者：
Garrett, Steven
中科院分区：
文献类型：
--
作者：
Draelos, Zoe D.;Carter, Eric;Garrett, Steven
背景：已开发出一种新的氨苯砜水凝胶制剂，可在临床上有效地局部施用氨苯砜，且全身吸收最少。目的：这些研究的目的是评估氨苯砜凝胶（5%）治疗痤疮的功效和安全性。方法：12 岁及以上寻常痤疮患者 (N = 3010) 参加了两项相同设计的为期 12 周的随机双盲研究，与载体凝胶相比，每天两次使用氨苯砜凝胶进行单一疗法，5%。 结果：在研究者的整体痤疮评估方面，氨苯砜凝胶治疗的患者取得了优异的结果（P
Background: A new aqueous gel formulation of dapsone has been developed that allows clinically-effective closes of dapsone to be administered topically with minimal systemic absorption.Objectives: The goal of these studies was to evaluate the efficacy and safety of dapsone gel, 5% in the treatment of acne.Methods: Patients 12 years of age and older with acne vulgaris (N = 3010) participated in two identically-designed 12-week, randomized, double-blind studies of twice-daily monotherapy with dapsone gel, 5%, versus a vehicle gel.Results: Dapsone gel-treated patients achieved superior results in terms of the investigator's global acne assessment (P