Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?
Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?
复制标题
DOI：
10.1155/2015/790203
复制
发表时间：
2015
影响因子：
--
通讯作者：
de la Motte CA
中科院分区：
文献类型：
--
作者：
Albeiroti S;Soroosh A;de la Motte CA
纤维化是一种使人衰弱的疾病，可导致受影响器官功能的损害。细胞外基质（ECM）分子的过度沉积是大多数纤维化组织的特征。由细胞因子或生长因子激活的成纤维细胞分化成肌成纤维细胞，其通过沉积ECM分子如胶原蛋白、纤连蛋白和结缔组织生长因子来驱动纤维化。转化生长因子-β（TGF-β）是主要的促纤维化细胞因子之一，其通过信号传导异常ECM调节而促进纤维化。透明质酸（HA）是一种主要的ECM糖胺聚糖，受TGF-β调节，其在纤维化中的作用正在显现。除了其作为水合、空间填充聚合物的作用外，HA还调节不同的细胞功能，并且已知其在伤口愈合和炎症中具有作用。重要的是，HA沉积在多种纤维化疾病中增加。在这篇综述中，我们强调了HA与纤维化之间的联系，并讨论了HA、其受体及其合成代谢和分解代谢酶在不同纤维化疾病中的作用。
Fibrosis is a debilitating condition that can lead to impairment of the affected organ's function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues. Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor. Transforming growth factor-β (TGF-β) is one of the major profibrotic cytokines which promotes fibrosis by signaling abnormal ECM regulation. Hyaluronan (HA) is a major ECM glycosaminoglycan that is regulated by TGF-β and whose role in fibrosis is emerging. Aside from its role as a hydrating, space filling polymer, HA regulates different cellular functions and is known to have a role in wound healing and inflammation. Importantly, HA deposition is increased in multiple fibrotic diseases. In this review we highlight studies that link HA to fibrosis and discuss what is known about the role of HA, its receptors, and its anabolic and catabolic enzymes in different fibrotic diseases.