In vivo models of hepatitis B and C virus infection.
In vivo models of hepatitis B and C virus infection.
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DOI：
10.1002/1873-3468.12157
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发表时间：
2016-07
期刊：
影响因子：
3.5
通讯作者：
Ploss A
中科院分区：
文献类型：
--
作者：
Winer BY;Ding Q;Gaska JM;Ploss A
在全球范围内，超过5亿人慢性感染乙型肝炎（HBV）、丁型肝炎（HDV）和/或丙型肝炎（HCV）病毒，这些病毒可导致严重的肝脏疾病。由于缺乏动物模型，对病毒持久性和发病机制的研究一直受到阻碍。HBV、HDV和HCV的种类和细胞宿主范围有限，它们只会强烈感染人类和黑猩猩，这给创建这种动物模型带来了挑战。在这篇综述中，我们将讨论物种间传播的障碍以及我们对HBV、HDV和HCV生命周期的理解所取得的进展。此外，我们将强调克服这些障碍的各种方法，从而促进这些嗜肝病毒的体内研究。
Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.