Effects of addictive drugs on adult neural stem/progenitor cells.
Effects of addictive drugs on adult neural stem/progenitor cells.
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DOI：
10.1007/s00018-015-2067-z
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Law PY
中科院分区：
文献类型：
--
作者：
Xu C;Loh HH;Law PY
神经干/祖细胞（NSPC）在成年神经发生中产生新生神经元、星形胶质细胞和少突胶质细胞之前经历一系列发育过程。在过去的十年中，对成瘾药物调节成人神经发生的研究强调了 NSPC 的作用。已证明这些药物以不同的方式调节成体NSPC的增殖、分化和存活，从而导致成体神经发生的不同后果。成瘾药物对 NSPC 的影响是通过多种不同的机制和途径发挥的，这些机制和途径相互作用，导致 NSPC 调节的复杂性。在此，我们回顾了不同成瘾药物对 NSPCs 的影响，以及相关的实验方法和范式。我们还讨论了目前对主要信号分子的理解，特别是这些效应背后的假定的共同机制。最后，我们回顾了该领域未来的研究方向。
Neural stem/progenitor cells (NSPCs) undergo a series of developmental processes before giving rise to newborn neurons, astrocytes and oligodendrocytes in adult neurogenesis. During the past decade, the role of NSPCs has been highlighted by studies on adult neurogenesis modulated by addictive drugs. It has been proven that these drugs regulate the proliferation, differentiation and survival of adult NSPCs in different manners, which results in the varying consequences of adult neurogenesis. The effects of addictive drugs on NSPCs are exerted via a variety of different mechanisms and pathways, which interact with one another and contribute to the complexity of NSPC regulation. Here, we review the effects of different addictive drugs on NSPCs, and the related experimental methods and paradigms. We also discuss the current understanding of major signaling molecules, especially the putative common mechanisms, underlying such effects. Finally, we review the future directions of research in this area.
影响因子：
2.3
作者：
Tsai, Shang-Yi;Lee, Chung-Ting;Hayashi, Teruo;Freed, William J.;Su, Tsung-Ping
通讯作者：
Su, Tsung-Ping