Maximum pull out force on DNA hybrids
Maximum pull out force on DNA hybrids
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DOI：
10.1016/s1296-2147(01)01287-2
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发表时间：
2001-12-01
期刊：
影响因子：
--
通讯作者：
De Gennes, PG
中科院分区：
文献类型：
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作者：
De Gennes, PG
我们从理论上讨论了两个胶体粒子之间的力F，每个胶体粒子携带一个单链DNA。两条链仅在（l）个连续碱基对的有限序列上互补。我们定义了一个调节长度u（-1）（几个碱基对）;在配对区域两端附近的调节区域中，张力仍然主要集中在一条单链上。但在中心部分（对于l > x（-1）），两个主链的负载相等。这导致断裂力F-c在lx < 1时随l线性增加，在lx > 1时饱和。(C)2001年科学院科学与医学版Elsevier SAS。
We discuss theoretically the force F between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (l) consecutive base pairs. We define an adjustment length u(-1) (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for l > x(-1) the two backbones are equally loaded. This leads to a rupture force F-c increasing linearly with l for lx < 1, and saturating for lx > 1. (C) 2001 Academie des science Editions scientifiques et medicales Elsevier SAS.