Hormonal interactions in regulation of androgen secretion.
Hormonal interactions in regulation of androgen secretion.
复制标题
雄激素分泌调节中的激素相互作用。
作者：
A. Bartke;A. A. Hafiez;F. Bex;S. Dalterio
本文综述了垂体激素在睾丸类固醇合成中的作用，重点介绍了卵泡刺激素(FSH)和催乳素(PRL)。睾丸雄激素的产生依赖于黄体生成素(L H)及其对间质细胞的作用。有证据表明，FSH增强了促黄体生成素对血浆睾酮(T)水平和雄激素依赖的男性附属生殖腺生长的作用。在性成熟过程中，FSH在提高睾丸对促黄体生成素刺激的反应性方面具有生理作用。催乳素增强内源性或外源性黄体生成素对睾丸类固醇合成的影响。PRL的作用似乎表明它直接作用于间质细胞。催乳素似乎也增加了胆固醇酯的储存，为类固醇的生成提供了前体。PRL可能在性成熟过程中起着非常重要的作用。本文认为，睾丸类固醇激素的调节依赖于一种腺体激素复合体，FSH和PRL都是该复合体的重要组成部分，睾丸类固醇激素的调节类似于卵巢的类固醇激素调节。
The action of pituitary hormones on testicular steroidogenesis is reviewed with particular focus on follicle stimulating hormone (FSH) and prolactin (PRL). Production of androgens by the testis depends on luteinizing hormone (LH) and the action of LH on the Leydig cells. There is evidence that FSH augments the action of LH on plasma testosterone (T) levels and on the growth of androgen-dependent male accessory reproductive glands. During sexual maturation FSH has a physiological role in increasing the responsiveness of the testes to LH stimulation. PRL augments the effect of endogenous or exogenous LH on testicular steriodogenesis. The effects of PRL seem to indicate direct action on the Leydig cells. PRL also seems to increase stores of cholesterol ester to provide a pool of precursors for steroidogenesis. PRL may be very important in sexual maturation. The review suggests that the regulation of testicular steroidogenesis depends on a complex of adenohypopyhseal hormones that FSH and PRL are both important components of this complex and that steroidogenesis regulation in the testis resembles steroidogenesis regulation in the ovary.