FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice.
FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice.
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FGF23 中和可改善慢性肾病小鼠的骨质量和钛植入物的骨整合
DOI：
10.1038/srep08304
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发表时间：
2015-02-10
影响因子：
4.6
通讯作者：
Yuan Q
中科院分区：
文献类型：
--
作者：
Sun N;Guo Y;Liu W;Densmore M;Shalhoub V;Erben RG;Ye L;Lanske B;Yuan Q
慢性肾脏病（CKD）是一个全球性的健康问题。FGF 23（一种磷酸尿激素）的血清水平在CKD的最早阶段升高，并且已发现与CKD患者的死亡率和发病率独立相关。本研究的目的是评估FGF 23中和是否能够改善钛种植体的骨质量和骨整合。在成年雌性小鼠中通过5/6肾切除诱导尿毒症。手术后，小鼠每周注射3次溶剂或FGF 23中和抗体（5 mg/kg体重）。 将实验钛植入物插入股骨远端。相对于媒介物处理的CKD小鼠，FGF 23中和显著增加血清磷酸盐、1，25（OH）2D和BUN，并降低血清PTH和FGF 23。对所述抗体的组织形态学分析表明，FGF 23中和使在媒介物处理的CKD小鼠中观察到的类骨质变性正常化。尽管骨-种植体接触比通过抗FGF 23抗体处理保持不变，但骨整合的强度通过FGF 23中和显著改善，如通过生物力学推入测试所证明的。我们的研究结果显示，FGF 23中和有效地改善CKD小鼠中钛种植体的骨质量和骨整合，表明FGF 23是CKD相关骨病的关键因素。
Chronic kidney disease (CKD) is a worldwide health problem. Serum levels of FGF23, a phosphaturic hormone, increase at the earliest stages of CKD and have been found to be independently associated with the mortality and morbidity of CKD patients. The purpose of this study was to evaluate whether FGF23 neutralization was able to improve bone quality and osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in adult female mice. Postsurgery, the mice were injected with vehicle or FGF23 neutralizing antibody (5 mg/kg body weight) 3 times a week. Experimental titanium implants were inserted in the distal end of the femurs. FGF23 neutralization significantly increased serum phosphate, 1,25(OH)2D and BUN and decreased serum PTH and FGF23, relative to vehicle-treated CKD mice. Histomorphometric analysis of the tibiae indicated that FGF23 neutralization normalized the osteoidosis observed in vehicle-treated CKD mice. Although bone-implant contact ratio remained unchanged by anti-FGF23 antibody treatment, the strength of osseointegration, as evidenced by a biomechanical push-in test, was significantly improved by FGF23 neutralization. Our findings revealed that FGF23 neutralization effectively improves bone quality and osseointegration of titanium implants in CKD mice, suggesting FGF23 as a key factor of CKD related bone diseases.
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DOI：
10.4103/1319-2442.124536
发表时间：
2014-01-01
影响因子：
0.5
作者：
Al Rukhaimi, Mona;Al Sahow, Ali;Shaheen, Faissal A. M.
通讯作者：
Shaheen, Faissal A. M.
影响因子：
13.6
作者：
Hallan, Stein I.;Coresh, Josef;Holmen, Jostein
通讯作者：
Holmen, Jostein
影响因子：
15.9
作者：
Carpenter, Thomas O.;Imel, Erik A.;Peacock, Munro
通讯作者：
Peacock, Munro
影响因子：
5.8
作者：
Goji, K;Ozaki, K;Matsuo, M
通讯作者：
Matsuo, M
影响因子：
3.1
作者：
Abraham, Bincy P.;Prasad, Preethi;Malaty, Hoda M.
通讯作者：
Malaty, Hoda M.