miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
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DOI：
10.3892/br.2018.1113
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发表时间：
2018-08
影响因子：
2.3
通讯作者：
Xie L
中科院分区：
文献类型：
--
作者：
Liu F;Hu H;Zhao J;Zhang Z;Ai X;Tang L;Xie L
MiR-124-3p与多种癌症有关。本研究旨在探讨miR-124-3p在胃癌中的表达及预后作用。功能研究表明，miR-124-3p在胃癌细胞中的异位过表达在体外抑制了细胞活力和平板集落形成，抑制了体内肿瘤的生长。原位杂交分析显示，miR-124-3p的低表达与临床分期、淋巴结转移、总生存期和无瘤生存率有关。此外，还观察到miR-124-3p通过靶向RAS相关的C3肉毒毒素底物1(Rac1)和特异性蛋白1(SP1)来抑制胃癌的发生。总而言之，这些结果表明miR-124-3p调控胃癌的潜在机制涉及靶向rac1和sp1。因此，miR-124-3p可能是胃癌患者生存和治疗策略的一个独立指标。
miR-124-3p has been implicated in a variety of cancers. The purpose of the present study was to investigate the expression, prognostic roles and functions of miR-124-3p in gastric cancer. Functional studies indicated that ectopic overexpression of miR-124-3p in gastric cancer cells suppressed cell viability and plate colony formation in vitro and tumor growth in vivo. In situ hybridization analysis demonstrated that decreased expression of miR-124-3p was associated with clinical stage and lymph node metastasis, as well as shorter overall survival and disease-free survival rates. Furthermore, it was observed that miR-124-3p repressed the carcinogenesis of gastric cancer by targeting Ras-related C3 botulinum toxin substrate 1 (Rac1) and specificity protein 1 (SP1). Collectively, these results indicate a potential underlying mechanism for the regulation of gastric cancer by miR-124-3p involving targeting of Rac1 and SP1. Thus, miR-124-3p may be an independent indicator of survival and treatment strategy for patients with gastric cancer.