Age-related degeneration of corpus callosum measured with diffusion tensor imaging
Age-related degeneration of corpus callosum measured with diffusion tensor imaging
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DOI：
10.1016/j.neuroimage.2006.02.008
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发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Suhara, Tetsuya
中科院分区：
文献类型：
--
作者：
Ota, Miho;Obata, Takayuki;Suhara, Tetsuya
胼胝体是连接大脑半球的主要连合处，有证据表明它会随着年龄的增长而发生变化。胼胝体的子区域（膝部、头体、前中体、后中体、峡部、压部）分别包含连接异模态和单模态相关皮质区域的纤维，并且已知胼胝体的异常与认知和行为异常相关。然而，对其子区域组织特征的变化知之甚少。我们使用扩散张量成像评估了胼胝体子区域的分数各向异性和平均扩散率与年龄相关的变化。我们研究了 42 名年龄 21-73 岁的健康右利手。性别 x 区域没有显着的相互作用。年龄与膝部（P < 0.001）、喙体（P < 0.001）和峡部（P = 0.005）的分数各向异性呈显着负相关。前中体分数各向异性与年龄呈负相关（P = 0.022）。年龄与胚芽（P = 0.001）、喙体（P = 0.002）、前中体（P = 0.001）和峡部（P = 0.001）的平均扩散率显着正相关。在其投影区域被认为容易受到正常老化影响的次区域中检测到了与年龄相关的变化。这表明胼胝体子区域的分数各向异性和平均扩散率值可以作为各个投影区域的干扰标记。 (c) 2006 Elsevier Inc. 保留所有权利。
The corpus callosum is the major commissure connecting the cerebral hemispheres, and there is evidence of its change with aging. The subregions of the corpus callosum (genu, rostral body, anterior midbody, posterior midbody, isthmus, splenium) respectively comprise fibers connecting heteromodal- and unimodal-associated cortical regions, and it is known that abnormalities of the corpus callosum are correlated with abnormalities in cognition and behavior. Yet, little is known about changes in the tissue characteristics of its sub-regions. We assessed age-related changes in fractional anisotropy and mean diffusivity in the sub-regions of the corpus callosum using diffusion tensor imaging. We studied 42 healthy right-handed individuals aged 21-73 years. There were no significant interactions of sex x region. Age has significant negative correlation with fractional anisotropy in the genu (P < 0.001), rostral body (P < 0.001), and isthmus (P = 0.005). Fractional anisotropy of the anterior midbody was correlated negatively with age at a trend level (P = 0.022). Age was significantly positively correlated with mean diffusivity in the germ (P = 0.001), rostral body (P = 0.002), anterior midbody (P = 0.001), and isthmus (P = 0.001). Age-related changes were detected in the sub-regions where their projection areas are thought to be vulnerable to normal aging. This suggested that fractional anisotropy and mean diffusivity values of the corpus callosum sub-regions could serve as markers of disturbance across the respective projection areas. (c) 2006 Elsevier Inc. All rights reserved.