Neuronal damage of the substantia nigra in HIV-1 infected brains
Neuronal damage of the substantia nigra in HIV-1 infected brains
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DOI：
10.1007/s004010051139
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发表时间：
2000-04-01
影响因子：
12.7
通讯作者：
Weis, S
中科院分区：
文献类型：
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作者：
Itoh, K;Mehraein, P;Weis, S
锥体外系运动障碍在HIV-1感染患者中常见。在本研究中，黑质的形态计量学分析，以检测神经元的变化，这可能有助于导致锥体外系运动功能障碍的HIV-1感染患者的发病机制。在HIV-1感染患者和年龄匹配的正常对照组中，确定了黑质旁核（前内侧核、前中间外侧核、后外侧核和后内侧核）中色素、非色素小神经元和非色素大神经元的数量密度和大小。在HIV-1感染的大脑中，总神经元的数密度（即。与正常对照相比，在黑质的所有研究的核中，着色的和非着色的）以及着色的神经元的一个特定的模式，增加和减少的非色素大和非色素小神经元观察。总神经元（色素和nonpigmented神经元）和色素神经元的大小显着减少，在所有调查的核HIV-1感染的大脑。结果表明，在黑质神经元变性通常发生，可能与锥体外系症状的HIV-1感染患者。
Extrapyramidal motor disorders are frequently noted in HIV-1-infected patients. In the present study, the substantia nigra was analyzed morphometrically to detect neuronal changes which might contribute to the pathogenetic mechanisms causing extrapyramidal motor dysfunction in HIV-1-infected patients. The numerical density and the size of pigmented, non-pigmented small, and non-pigmented large neurons in four nuclei of the substantia nigra pars compacta (antero-medial, antero-intermediolateral, postero-lateral, and postero-medial nuclei) in HIV-1-infected patients and in age-matched normal controls were determined. In HIV-1-infected brains, the numerical density of total neurons (i.e.. pigmented and non-pigmented) as well as of pigmented neurons was significantly decreased, whereas that of non-pigmented neurons was not significantly changed in all investigated nuclei of the substrantia nigra as compared to normal controls. A specific pattern of increase and decrease of nonpigmented large and non-pigmented small neurons was observed. The size of total neurons (pigmented and nonpigmented neurons) and of pigmented neurons was significantly reduced in all investigated nuclei of HIV-1-infected brains. The results suggest that neuronal degeneration in the substantia nigra commonly occurs and may be related to extrapyramidal symptoms in HIV-1-infected patients.