Stroke after varicose vein foam injection sclerotherapy
Stroke after varicose vein foam injection sclerotherapy
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DOI：
10.1016/j.jvs.2005.09.032
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发表时间：
2006-01-01
影响因子：
4.3
通讯作者：
Shanik, G
中科院分区：
文献类型：
--
作者：
Forlee, MV;Grouden, M;Shanik, G
本文报告一例卵圆孔未闭静脉曲张患者接受泡沫注射硬化剂治疗后发生缺血性卒中。泡沫注射硬化疗法已经在静脉曲张的微创治疗中复兴。美国食品和药物管理局于2003年停止了一项关于聚多卡醇微泡沫商业制剂的2期临床试验，因为担心可能发生气体栓塞。这些审判于2005年7月重新开始。神经系统并发症，如短暂性视觉障碍和短暂性意识模糊状态以前曾有报道。该病例以其强有力的间接证据说明了使用该技术发生栓塞并发症的可能性。
This report describes an ischemic stroke after foam injection sclerotherapy of varicose veins in a patient with a patent foramen ovale. Foam injection sclerotherapy has created resurgence in the minimally invasive treatment of varicose veins. The United States Food and Drug Administration halted a clinical phase 2 trial of a commercial preparation of polidocanol microfoam in 2003 because of concerns relating to possible gas embolism. These trials were recommenced in July 2005. Neurologic complications such as transient visual disturbances and transient confusional states have previously been reported. This case, with its strong circumstantial evidence, illustrates the previously unconfirmed potential for embolic complications using this technique.