Gastrointestinal ulcer formation in rabbits immunized with prostaglandin E2.
Gastrointestinal ulcer formation in rabbits immunized with prostaglandin E2.
复制标题
前列腺素 E2 免疫兔子的胃肠道溃疡形成。
DOI：
10.1016/0016-5085(87)90436-7
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发表时间：
1987
期刊：
影响因子：
29.4
通讯作者：
Feldman,M
中科院分区：
文献类型：
--
作者：
Redfern,JS;Blair3rd,AJ;Lee,E;Feldman,M
12只用前列腺素E_2-甲状腺球蛋白结合物免疫的兔产生循环前列腺素E_2抗体，其中10只出现溃疡，多见于胃，较少见于小肠。前列腺素E_2和6-酮前列腺素F1α联合免疫组与单独用前列腺素E_2免疫组相比，胃溃疡数量明显增加。口服前列腺素E_2不能预防前列腺素E_2免疫兔的胃肠道溃疡。胃肠道溃疡最早在开始免疫后6wk就会发生，并经常穿孔并导致死亡。用甲状腺球蛋白载体免疫的兔(对照组)既没有出现前列腺素E2抗体，也没有出现溃疡。用前列腺素E_2高免疫血浆被动免疫未免疫的兔，9天内出现急性胃溃疡，而被动转移非免疫血浆不产生溃疡。后一项发现表明，前列腺素E2抗体本身是导致溃疡形成的原因。
Circulating prostaglandin E2antibodies were produced in 12 rabbits immunized with prostaglandin E2-thyroglobulin conjugate and ulcers occurred in 10, usually in the stomach and less often in the small intestine. Immunization of rabbits with both prostaglandin E2and 6-keto prostaglandin F1αsignificantly increased the number of gastric ulcers compared with rabbits immunized with prostaglandin E2alone. Gastrointestinal ulceration in prostaglandin E2-immunized rabbits was not prevented by oral enprostil. Gastrointestinal ulcers occurred as early as 6 wk after beginning immunization and often perforated with resulting fatality. Neither prostaglandin E2antibodies nor ulcers developed in rabbits immunized with thyroglobulin vehicle (controls). Passive immunization of unimmunized rabbits with prostaglandin E2-hyperimmune plasma led to acute gastric ulcers within 9 days, whereas passive transfer of nonimmune plasma did not produce ulcers. This latter finding suggests that prostaglandin E2antibodies per se were responsible for ulcer formation.