Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
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DOI：
10.1172/jci44339
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发表时间：
2011-01-01
影响因子：
15.9
通讯作者：
Weissleder, Ralph
中科院分区：
文献类型：
--
作者：
Gaglia, Jason L.;Guimaraes, Alexander R.;Weissleder, Ralph
1A型糖尿病（T1 D）是一种自身免疫性疾病，其特征在于胰岛的白细胞浸润。在理解、预防和治疗T1 D方面取得进展的主要障碍是不能“看到”疾病的存在、进展或消退，特别是在隐匿期。我们报道了一种在活动性胰岛炎患者的靶器官水平可视化T1 D的非侵入性方法的发展。具体地，我们可视化了胰岛炎症，通过微血管变化和单核细胞/巨噬细胞募集和活化来表现，使用磁性纳米颗粒（MNP）的磁共振成像作为该方法的原理证明，输注的ferumoxtran-10纳米颗粒的成像允许胰腺的有效可视化和最近的MNP在T1 D患者胰腺中积累的观察结果为利用这种非侵入性成像方法来跟踪T1 D进展和监测免疫调节剂清除胰岛炎的能力打开了大门
Type 1A diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration of the pancreatic islets of Langerhans A major impediment to advances in understanding, preventing, and curing T1D has been the inability to "see" the disease inmate, progress, or regress, especially during the occult phase Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis Specifically, we visualized islet inflammation, manifest by microvascular changes and monocyte/macrophage recruitment and activation, using magnetic resonance imaging of magnetic nanoparticles (MNPs) As a proof of principle for this approach, imaging of infused ferumoxtran-10 nanoparticles permitted effective visualization of the pancreas and distinction of recent-onset diabetes patients from nondiabetic controls The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis