The roles of interleukins in perfusion recovery after peripheral arterial disease.
The roles of interleukins in perfusion recovery after peripheral arterial disease.
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白细胞介素在外周动脉疾病后灌注恢复中的作用。
DOI：
10.1042/bsr20171455
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发表时间：
2018
影响因子：
4
通讯作者：
Wang Tao
中科院分区：
文献类型：
--
作者：
Chen Lingdan;Liu Hanwei;Yuan Mingjie;Lu Wenju;Wang Jian;Wang Tao
在外周动脉疾病（PAD）患者中，供应腿部的主要动脉闭塞使血流依赖于新血管形成的能力。目前没有能够增加缺血肢体的新血管形成并直接治疗PAD的主要问题的药物。越来越多的证据支持炎症在PAD后血管重塑和灌注恢复中起重要作用的观点。白细胞介素（IL）是一组在炎症过程中产生的蛋白质，被认为在组织缺血后的血管生成和动脉生成中起重要作用。本文就IL在PAD后血流灌注恢复中作用的最新临床和实验研究进展作一综述。
In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the leg makes blood flow dependent on the capacity of neovascularization. There is no current medication that is able to increase neovascularization to the ischemic limb and directly treat the primary problem of PAD. An increasing body of evidence supports the notion that inflammation plays an important role in the vascular remodeling and perfusion recovery after PAD. Interleukins (ILs), a group of proteins produced during inflammation, have been considered to be important for angiogenesis and arteriogenesis after tissue ischemia. This review summarizes the latest clinical and experimental developments of the role of ILs in blood perfusion recovery after PAD.