Expression of interleukin-8 receptor A predicts poor outcome in patients with nasopharyngeal carcinoma
Expression of interleukin-8 receptor A predicts poor outcome in patients with nasopharyngeal carcinoma
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DOI：
10.1097/01.mlg.0000150675.37860.f7
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Yoshizaki, T
中科院分区：
文献类型：
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作者：
Horikawa, T;Kaizaki, Y;Yoshizaki, T
目的/假设：作者最近证实，IL-8是由编码潜伏膜蛋白1的EB病毒诱导的，IL-8在肿瘤细胞中过表达，并与鼻咽癌的血管生成密切相关。本研究的目的是探讨IL-8受体在鼻咽癌中的表达及其作用。研究设计：对鼻咽癌患者的临床资料进行回顾性分析，并对其组织进行免疫组织化学研究。方法：采用免疫组织化学方法检测30例鼻咽癌组织中两种高亲和力IL-8受体IL-8受体A(IL8RA)和IL-8受体B(IL8RB)的表达。结果：两种IL-8受体均表达于瘤巢及周围间质的微血管上。有趣的是，它们也在肿瘤细胞上大量表达。IL8RA和IL8RB的表达与性别、转移和临床分期无关。然而，IL8RA在肿瘤中的表达与总生存率显著相关(P=0.0045)。尽管IL8RA阴性患者的5年总存活率估计为68.2%，但IL8RA阳性患者的5年总存活率仅为33.3%。结论：IL8RA在鼻咽癌组织中的表达可作为判断鼻咽癌预后不良的重要指标。
Objectives/Hypothesis.- The authors recently demonstrated that interleukin-8 (IL-8) is induced by Epstein-Barr virus encoding latent membrane protein 1 and that IL-8 is overexpressed in tumor cells and correlates significantly with angiogenesis in nasopharyngeal carcinoma. The present objective was to investigate the expressions and the roles of IL-8 receptors in nasopharyngeal carcinoma. Study Design: Retrospective patient file review and immunohistochemical study of tissues of patients with nasopharyngeal carcinoma. Methods: The authors examined the expressions of two high-affinity IL-8 receptors, IL-8 receptor A IL8RA) and IL-8 receptor B (IL8RB), in 30 patients with nasopharyngeal carcinoma by immunohistochemical analysis. Results: As expected, both IL-8 receptors were expressed on microvessels in tumor nests and surrounding stroma. Interestingly, they were also abundantly expressed on tumor cells. The expressions of IL8RA and IL8RB had no associations with gender, metastasis, or clinical stage. However, the expression of IL8RA in tumors significantly correlated with a shorter overall survival rate (P =.0045). Although the estimated 5-year overall survival rate for IL8RA-negative patients was 68.2%, that in IL8RA-positive patients was only 33.3%. Conclusion: The study results suggest that the expression of IL8RA in tumor cells becomes an important indicator of poor prognosis in nasopharyngeal carcinoma.