Synergistic action of polyanionic and non‐polar cofactors in fibrillation of human islet amyloid polypeptide
Synergistic action of polyanionic and non‐polar cofactors in fibrillation of human islet amyloid polypeptide
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DOI：
10.1016/j.febslet.2007.03.030
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发表时间：
2007-04
期刊：
影响因子：
3.5
通讯作者：
T. Konno;S. Oiki;T. Morii
中科院分区：
文献类型：
--
作者：
T. Konno;S. Oiki;T. Morii
近年来的研究表明，多种溶质辅助因子的协同作用可能在致病性多肽的淀粉样型纤维形成中起重要作用。为了支持这一观点，我们在含有多阴离子和非极性溶剂的介质中进行了人胰岛淀粉样多肽（IAPP）的聚集实验。结果表明，只有当多阴离子和非极性溶质共存时，才会发生亚微摩尔IAPP的纤颤。两个独立的辅助因子的作用的简单总和不能解释协同作用。我们认为，这种多阴离子和非极性环境的协同作用可以大大改变人体淀粉样蛋白的形成。
Recent studies have led us to suppose that synergistic action of multiple solute cofactors could play substantial roles in amyloid-type fibrillogenesis of pathogenic polypeptides. To support this view, we performed aggregation experiments of human islet amyloid polypeptide (IAPP) in media containing both polyanions and non-polar solvents. The results demonstrated that the fibrillation at sub-micromolar IAPP occurred only when polyanionic and non-polar solutes coexist. A simple sum of two independent cofactor’s effects could not account for the synergistic action. We propose that this synergy of polyanionic and nonpolar milieus could substantially modify the amyloidgenesis in the human body.