Nonsense-mediated mRNA decay and development: shoot the messenger to survive?
Nonsense-mediated mRNA decay and development: shoot the messenger to survive?
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DOI：
10.1042/bst0381500
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发表时间：
2010-12-01
影响因子：
3.9
通讯作者：
Palacios, Isabel M.
中科院分区：
文献类型：
--
作者：
Crespo, Marta Vicente;Palacios, Isabel M.
NMD NMD（无义介导的mRNA衰变）是一种监视机制，其降解含有无义突变的转录物，从而防止潜在有害的截短蛋白的翻译。尽管NMD的机制细节正在逐渐被理解，但这种RNA监视途径的生理作用仍然在很大程度上未知。（上移码抑制子1）这些发现可能反映了NMD在动物发育过程中的重要作用。或者，upf 1和upf 2突变体的致死表型可能是由于它们在NMD独立过程中的功能，本文描述了当NMD因子在各种生物体中突变时观察到的表型，并讨论了可能揭示NMD在生物体细胞生长和发育中的功能的发现。
NMD (nonsense mediated mRNA decay) is a surveillance mechanism that degrades transcripts containing nonsense mutations preventing the translation of potentially harmful truncated proteins Although the mechanistic details of NMD are gradually being understood the physiological role of this RNA surveillance pathway still remains largely unknown The core NMD genes Upf1 (up frameshift suppressor 1) and Upf2 are essential for animal viability in the fruitfly mouse and zebrafish These findings may reflect an important role for NMD during animal development Alternatively the lethal phenotypes of upf1 and upf2 mutants might be due to their function in NMD independent processes In the present paper we describe the phenotypes observed when the NMD factors are mutated in various organisms and discuss findings that might shed light on the function of NMD in cellular growth and development of an organism