Immunometabolism governs dendritic cell and macrophage function.
Immunometabolism governs dendritic cell and macrophage function.
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DOI：
10.1084/jem.20151570
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发表时间：
2016-01-11
期刊：
影响因子：
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通讯作者：
Pearce EJ
中科院分区：
文献类型：
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作者：
O'Neill LA;Pearce EJ
在这篇综述中，奥尼尔和皮尔斯讨论了最近有趣的发现代谢变化调节功能的巨噬细胞和树突状细胞。最近对树突状细胞（DC）和巨噬细胞的细胞内代谢的研究为这些先天性和适应性免疫的关键控制器的功能提供了新的见解。这两种细胞类型都经历了深刻的代谢重编程，以响应环境线索，如缺氧或营养改变，但重要的是也响应危险信号和细胞因子。琥珀酸盐和柠檬酸盐等代谢产物对巨噬细胞的功能有直接影响。DC的免疫原性和耐受原性也分别由合成代谢和分解代谢过程决定。这些发现为炎症性疾病和癌症的治疗操作提供了新的前景。
In this review, O’Neill and Pearce discuss recent intriguing findings on metabolic changes regulating the function of macrophages and dendritic cells. Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammatory diseases and cancer.