Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2
Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2
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DOI：
10.1254/jphs.fp0050211
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发表时间：
2005-07-01
影响因子：
3.5
通讯作者：
Horie, M
中科院分区：
文献类型：
--
作者：
Matsuyama, S;Doe, N;Horie, M
NELL 2是一种神经元特异性的血小板反应蛋白-I样细胞外蛋白，含有六个表皮生长因子样结构域。我们先前通过基因靶向破坏了小鼠的NELL 2基因，并表明NELL 2缺陷小鼠的齿状回中的长时程增强在体内得到增强。为了进一步阐明NELL 2的生理作用，我们对NELL 2（-/-）及其杂合对照小鼠进行了行为表征。NELL 2缺陷小鼠在Morris水迷宫任务中表现出学习障碍。然而，我们观察到NELL 2（-/-）和NELL 2（+/-）小鼠之间的被动回避学习没有差异。这些观察结果表明，NELL 2起着重要的作用，在校园依赖的空间学习和情绪学习并不严重依赖于NELL 2。
NELL2 is a neuron-specific thrombospondin-I-like extracellular protein containing six epidermal growth factor-like domains. We previously disrupted the NELL2 gene in mice by gene targeting and showed that long-term potentiation is enhanced in vivo in the dentate gyrus of NELL2-deficient mice. To further elucidate the physiological roles of NELL2, we performed a behavioral characterization of NELL2(-/-) and their heterozygous control mice. NELL2-deficient mice exhibited learning impairment in the Morris water maze task. However, we observed no difference in passive avoidance learning between NELL2(-/-) and NELL2(+/-) mice. These observations suggest that NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2.