Using the PhenX Toolkit to Select Standard Measurement Protocols for Your Research Study.
Using the PhenX Toolkit to Select Standard Measurement Protocols for Your Research Study.
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DOI：
10.1002/cpz1.149
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发表时间：
2021-05
期刊：
影响因子：
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通讯作者：
Hamilton CM
中科院分区：
文献类型：
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作者：
Cox LA;Hwang S;Haines J;Ramos EM;McCarty CA;Marazita ML;Engle ML;Hendershot T;Pan HH;Hamilton CM
PhenX的目标（表型和eXposures的共识措施）是促进标准测量协议的使用，并帮助研究人员确定合作研究和交叉研究分析的机会，从而增加个别研究的影响。PhenX工具包（https：//www.phenxtoolkit.org/）提供高质量，完善的测量协议，以评估人类参与者的研究中的表型和暴露。该工具包载有代表29个研究领域的协议和6个专业协议集，这些协议集增加了工具包在特定研究领域的深度（例如，COVID-19、健康的社会决定因素[SDoH]、血液科学研究[BSR]、心理健康研究[MHR]、烟草监管研究[TRR]和物质滥用和成瘾[SAA]）。协议被建议列入PhenX工具包由领域专家工作组使用的共识过程，包括从科学界的投入。对于每一个PhenX协议，该工具包提供了详细的说明，列入的理由，和支持文件。用户可以浏览工具包中的协议，使用关键字搜索工具包，或使用浏览协议树来识别感兴趣的协议。该PhenX工具包提供了数据字典与基因型和表型数据库兼容（dbGaP），研究电子数据采集（REDCap）数据提交兼容性，和数据收集工具，以帮助研究人员将PhenX协议纳入他们的研究设计。该PhenX工具包提供的资源，以帮助用户确定使用PhenX协议发表的研究。版权所有© 2021作者。由Wiley Periodicals LLC出版。 基本协议：使用PhenX工具包来支持或扩展研究设计
The goals of PhenX (consensus measures for Phenotypes and eXposures) are to promote the use of standard measurement protocols and to help investigators identify opportunities for collaborative research and cross‐study analysis, thus increasing the impact of individual studies. The PhenX Toolkit (https://www.phenxtoolkit.org/) offers high‐quality, well‐established measurement protocols to assess phenotypes and exposures in studies with human participants. The Toolkit contains protocols representing 29 research domains and 6 specialty collections of protocols that add depth to the Toolkit in specific research areas (e.g., COVID‐19, Social Determinants of Health [SDoH], Blood Sciences Research [BSR], Mental Health Research [MHR], Tobacco Regulatory Research [TRR], and Substance Abuse and Addiction [SAA]). Protocols are recommended for inclusion in the PhenX Toolkit by Working Groups of domain experts using a consensus process that includes input from the scientific community. For each PhenX protocol, the Toolkit provides a detailed description, the rationale for inclusion, and supporting documentation. Users can browse protocols in the Toolkit, search the Toolkit using keywords, or use Browse Protocols Tree to identify protocols of interest. The PhenX Toolkit provides data dictionaries compatible with the database of Genotypes and Phenotypes (dbGaP), Research Electronic Data Capture (REDCap) data submission compatibility, and data collection worksheets to help investigators incorporate PhenX protocols into their study design. The PhenX Toolkit provides resources to help users identify published studies that used PhenX protocols. © 2021 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol: Using the PhenX Toolkit to support or extend study design