POUOSIDES A-E, NOVEL TRITERPENE GALACTOSIDES FROM A MARINE SPONGE, ASTEROPUS SP
POUOSIDES A-E, NOVEL TRITERPENE GALACTOSIDES FROM A MARINE SPONGE, ASTEROPUS SP
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DOI：
10.1021/jo00252a006
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发表时间：
1988-08-19
影响因子：
3.6
通讯作者：
GUNASEKERA, SP
中科院分区：
文献类型：
--
作者：
KSEBATI, MB;SCHMITZ, FJ;GUNASEKERA, SP
从太平洋海绵Asteropus sp.中分离出五个新的三萜半乳糖苷，即pouosides A-E（1-5）。pouosides糖苷配基的碳骨架与C40类胡萝卜素的碳骨架相似，是天然三萜中新发现的。通过波谱数据，特别是广泛的1H和13 C NMR数据和2D NMR实验确定结构。从同一海绵中分离出一种掺入氨基糖的新型皂苷。Pouoside A，1，具有细胞毒性。
Five new triterpene galactosides, pouosides A-E (1-5), have been isolated from a Pacific marine sponge, Asteropus sp. The carbon skeleton of the pouoside aglycons is new for naturally occurring triterpenes and parallels that of the C40 carotenoids. Structures were determined from spectroscopic data, especially extensive 1H and 13C NMR data and 2D NMR experiments. A novel saponin in which amino sugars are incorporated was isolated from the same sponge. Pouoside A, 1, is cytotoxic.