Basis for use of digoxin in small birds.
Basis for use of digoxin in small birds.
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在小型鸟类中使用地高辛的基础。
DOI：
10.1111/j.1365-2885.1987.tb00114.x
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发表时间：
1987
影响因子：
1.3
通讯作者：
P. S. Stalnaker
中科院分区：
文献类型：
--
作者：
Robert L. Hamlin;P. S. Stalnaker
为了确定地高辛在虎皮鹦鹉体内的有益血浆浓度，在25只平均体重31 g的成熟麻雀中，15只给予0.625 mg/kg地高辛，10只给予0.3125 mg/kg地高辛作为含0.05 mg/ml的酊剂口服。在24小时内，每隔5次抽取1 / 5的鸟的血液样本显示，这些剂量地高辛的半衰期分别为26小时和21小时，这表明每天服用一次地高辛可以维持血药浓度。9只平均体重28 g的成年虎皮鹦鹉中，有3只每天口服0.36、0.18、0.09 mg/kg，连续5天。第5次给药后12 h地高辛血药浓度分别为12.8、7.6和4.8 ng/ml。在此基础上，4只虎皮鹦鹉饲喂0.02 mg/kg/d，连续5 d。平均血浆浓度为1.6 ng/ml，被认为在哺乳动物的治疗范围内，尽管推荐剂量与质量成反比，因此0.02 mg/kg低于估计值。因此，为了提供0.0005 mg的日剂量，需要将该酊剂按1:4稀释0.05 ml。
To establish a dose of digoxin for beneficial plasma concentrations in budgerigars, 15 of 25 mature sparrows of mean weight 31 g were given 0.625 mg/kg digoxin and 10 were given 0.3125 mg/kg orally as a tincture containing 0.05 mg/ml. Blood samples from one fifth of the birds at each of 5 intervals over 24 hours showed that half-lives of these doses of digoxin were 26 and 21 hours, respectively, indicating that digoxin given once daily would maintain plasma concentrations. Three of 9 mature budgerigars of mean weight 28 g were given orally 1 of 3 daily doses for 5 days: 0.36, 0.18, 0.09 mg/kg. Digoxin concentrations at 12 hours after the fifth dose were 12.8, 7.6 and 4.8 ng/ml plasma. Based on this, 4 budgerigars were given 0.02 mg/kg/day for 5 days. Mean plasma concentration was 1.6 ng/ml, considered to be within the therapeutic range in mammals, although the recommended dosage varies inversely to mass, so 0.02 mg/kg is lower than that estimated. Thus to provide a daily dose of 0.0005 mg, 0.05 ml of a 1:4 dilution of the tincture is required.