CHEMOATTRACTANT LYMPHOKINES SPECIFIC FOR THE HELPER INDUCER LYMPHOCYTE-T SUBSET
CHEMOATTRACTANT LYMPHOKINES SPECIFIC FOR THE HELPER INDUCER LYMPHOCYTE-T SUBSET
复制标题
DOI：
10.1016/0008-8749(85)90299-0
复制
发表时间：
1985-01-01
影响因子：
4.3
通讯作者：
BEER, DJ
中科院分区：
文献类型：
--
作者：
BERMAN, JS;CRUIKSHANK, WW;BEER, DJ
富含t淋巴细胞的炎症部位的细胞含量部分依赖于化学引诱因子的原位加工。我们之前已经描述了三种t淋巴细胞特异性趋化淋巴因子；一种趋化动力学因子、淋巴细胞趋化因子（LCF, MW 56000）和两种不同的淋巴细胞迁移抑制因子（lyif75k, MW 75000；和lyif35k， MW 35000）。这些因子是由人T细胞对抗原、豆蛋白A或组胺刺激的反应产生的。在这篇文章中，我们报道了LCF和lyif35k分别由OKT8+（抑制/细胞毒性）和OKT4+（辅助/诱导剂）淋巴细胞产生，并且是OKT4+淋巴细胞亚群的选择性化学引诱剂。lyif75k由OKT4+细胞产生，可抑制OKT4+和OKT8+淋巴细胞的迁移。通过浸润淋巴细胞亚群产生LCF和LyMIF35K可能是一种机制，即非活化的辅助/诱导剂T淋巴细胞被选择性地募集到炎症部位。
The cellular content of T-lymphocyte-rich inflammatory sites is dependent in part on the in situ elaboration of chemoattractant factors. We have previously described three T-lymphocyte-specific chemoattractant lymphokines; a chemokinetic factor, lymphocyte chemoattractrant factor (LCF, MW 56,000), and two distinct lymphocyte migration inhibitory factors (LyMIF75K, MW 75,000; and LyMIF35K, MW 35,000). These factors are produced by human T cells in response to antigen, concanavalin A, or histamine stimulation. In this communication, we report that LCF and LyMIF35K are produced by OKT8+ (suppressor/cytotoxic) and OKT4+(helper/inducer) lymphocytes, respectively, and are selectively chemoattractant for the OKT4+ lymphocyte subset. LyMIF75K is produced by OKT4+ cells and inhibits both OKT4+ and OKT8+ lymphocyte migration. Production of LCF and LyMIF35K by infiltrating lymphocyte subsets may be one mechanism whereby unactivated helper/inducer T lymphocytes are selectively recruited to sites of inflammation.