Identification of a type 1 insulin-like growth factor binding protein (IGF BP) in serum from rats with diabetes mellitus.
Identification of a type 1 insulin-like growth factor binding protein (IGF BP) in serum from rats with diabetes mellitus.
复制标题
糖尿病大鼠血清中 1 型胰岛素样生长因子结合蛋白 (IGF BP) 的鉴定。
DOI：
10.1016/0006-291x(89)92304-8
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
Becker,RE
中科院分区：
文献类型：
--
作者：
Unterman,TG;Oehler,DT;Becker,RE
在链脲佐菌素诱导的糖尿病动物中，循环胰岛素样生长因子结合蛋白（IGF BP）活性增加。通过SDS/PAGE分离BP用于配体和免疫印迹分析，揭示了32，000分子量BP在糖尿病血清中存在并增加。这种BP在免疫学上不同于低分子量胎鼠BP（rBP 2），并且与胰岛素依赖型糖尿病患者中升高的人羊水BP（hBP 1）相关。
Circulating insulin-like growth factor binding protein (IGF BP) activity is increased in animals with streptozotocin-induced diabetes. Separation of BPs by SDS/PAGE for ligand and immunoblot analysis revealed that a 32,000 molecular weight BP is present and increased in diabetic serum. This BP is immunologically distinct from the low molecular weight fetal rat BP (rBP2) and is related to the human amniotic fluid BP (hBP1) that is increased in patients with insulin dependent diabetes mellitus.