The interaction between the immune system and the peripheral sensory nerves in pruritus.
The interaction between the immune system and the peripheral sensory nerves in pruritus.
复制标题
瘙痒症中免疫系统与周围感觉神经之间的相互作用。
DOI：
10.1093/intimm/dxab076
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发表时间：
2021
影响因子：
4.4
通讯作者：
K. Kabashima
中科院分区：
文献类型：
--
作者：
H. Irie;K. Kabashima
瘙痒是一种皮肤特有的感觉，见于各种皮肤病，特别是炎症性皮肤病，如特应性皮炎，并与其发病机制密切相关。瘙痒还对患者的睡眠和精神健康造成不利影响，给日常生活带来沉重负担。因此，控制瘙痒对保持健康很重要。瘙痒的发生机制最近已被阐明，各种瘙痒介质的发现、特定神经传导瘙痒的识别以及对瘙痒感知知识的积累使人们对瘙痒的产生、传递和识别的各个方面有了更好的了解。对于皮炎引起的瘙痒，渗入皮肤的免疫细胞会分泌炎性细胞因子，这些细胞因子也会作为瘙痒的媒介作用于周围神经，并引发炎症反应。有趣的是，越来越多的证据表明，周围神经也通过神经肽参与炎症。在本文中，我们总结了免疫细胞分泌的瘙痒介质的研究结果，以及周围神经与免疫相互作用在瘙痒中的作用。
Pruritus is a skin-specific sensation that is observed in various skin diseases, especially in inflammatory skin diseases such as atopic dermatitis, and is deeply involved in their pathogenesis. Pruritus also adversely affects patients' sleep and mental health, placing a heavy burden on daily life. As such, pruritus control is important to the maintenance of health. The mechanism of pruritus has recently been clarified and the discovery of various pruritus mediators, the identification of specific nerves that transmit pruritus and the accumulation of knowledge on pruritus perception have led to a better understanding of all aspects of pruritus generation, transmission and recognition. In the case of pruritus caused by dermatitis, immune cells infiltrating the skin secrete inflammatory cytokines, which also act on peripheral nerves as pruritus mediators and induce an inflammatory response. Interestingly, there has been accumulating evidence that peripheral nerves are also involved in the inflammation via neuropeptides. In this article, we summarize the findings on pruritus mediators secreted by immune cells and the roles of peripheral nerves in pruritus in terms of their interactions with immunity.