Arginine vasopressin inoculates against age-related changes in temporal memory.
Arginine vasopressin inoculates against age-related changes in temporal memory.
复制标题
精氨酸加压素可预防与年龄相关的时间记忆变化。
DOI：
10.1111/j.1749-6632.1985.tb37608.x
复制
发表时间：
1985
影响因子：
5.2
通讯作者：
Church,RM
中科院分区：
文献类型：
--
作者：
Meck,WH;Church,RM
检查大鼠时间记忆的年龄相关变化，并研究在动物成熟（10-23月龄）时给予精氨酸抗利尿素（AVP）是否会防止或减少大鼠变老（27-30月龄）时的这些变化。20只10岁雄性COBS CD大鼠在每组30次训练前20分钟分别腹腔注射AVP（0.08压力单位/kg）或生理盐水。采用20秒峰值程序。结果表明,AVP有2对性能的影响:它减少颞可变性的歧视和转移高峰时间明显早于20秒。随着年龄的党卫军生理盐水对照组(年龄的观众莫)增加,颞可变性的歧视的增加,峰值时间转移明显晚于20秒。相比之下,学生接受了AVP 10-23 mo的年龄没有增加高峰时间当他们研究莫老。由此可见，AVP对成年大鼠的时间记忆有一定的抑制作用。（11 ref）（PsycINFO Database Record (c) 2016 APA，版权所有）
Examined age-related changes in the temporal memory of rats and investigated whether arginine vasopressin (AVP) administered when the animals were mature (10–23 mo of age) would prevent or reduce these changes when the rats became old (27–30 mo of age). 20 10-mo-old male COBS CD rats received either an intraperitoneal injection of AVP (0.08 pressor units/kg) or saline 20 min prior to each of 30 sessions of training. A 20-sec peak procedure was used. Results show that the AVP had 2 effects on performance: It decreased the variability of the temporal discrimination and shifted the peak time significantly earlier than 20 sec. As the age of Ss in the saline control group (27–30 mo of age) increased, the variability of the temporal discrimination increased and the peak time shifted significantly later than 20 sec. In contrast, Ss that received AVP at 10–23 mo of age did not have an increase in the peak time when they were 27–30 mo old. It is concluded that AVP treatment of mature rats prevents some changes in temporal memory when the animals become old.(11 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)