Putative Effect of Spirulina Extract on Enzyme Activities Participating in Lipid and Carbohydrate Digestion Processes
Putative Effect of Spirulina Extract on Enzyme Activities Participating in Lipid and Carbohydrate Digestion Processes
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DOI：
10.1080/19390211.2018.1472166
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发表时间：
2019-09-03
影响因子：
2.5
通讯作者：
Morita, Kyoji
中科院分区：
文献类型：
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作者：
Kishibuchi, Reina;Nishibori, Naoyoshi;Morita, Kyoji
热量摄入过多被公认为代谢综合征的主要原因，因此均衡饮食和适度运动可以被认为是避免能量利用和储存紊乱的最有效措施。此外，作为改善能量平衡紊乱的任何其他方法，延迟和降低能量源、脂质和碳水化合物的消化和/或吸收可能是有效的。为初步筛选延缓和降低天然物质消化吸收过程的有效物质，以钝顶螺旋藻为原料，制备了去蛋白提取物，并研究了该提取物对脂肪酶和α-葡萄糖苷酶活性的影响。该提取物显示出抑制脂肪酶活性，但不抑制α-葡糖苷酶活性，因此提出了该提取物由于减少肠道中脂质的消化和吸收而防止血液甘油三酯（TG）水平餐后升高的可能性。因此，似乎可以推测，螺旋藻的非蛋白质成分可能能够有效地改善能量平衡紊乱，这是由于通过减少代谢综合征患者对脂质的吸收来抑制热量的过量摄入。
Excessive calorie intake is generally accepted as a primary cause of metabolic syndrome, and therefore a well-balanced diet and moderate exercise can be expected to be the most effective measures to avoid the disorder of energy utilization and storage. Furthermore, as any other way to improve the disorder of energy balance, it may be effective to delay and lower the digestion and/or absorption of energy sources, lipids, and carbohydrates. As a primary screening of effective substances to delay and lower the digestion and absorption processes among natural materials, the protein-deprived extract was prepared from blue-green algae Spirulina platensis, and the effect of this extract on lipase and alpha-glucosidase activities was examined. The extract was shown to inhibit lipase activity but not alpha-glucosidase activity, thus proposing the possibility that the extract prevented the postprandial elevation of blood triglyceride (TG) levels as a result of reducing the digestion and absorption of lipids in the intestinal tract. Therefore, it seems possible to speculate that nonprotein components of Spirulina may be able to effectively improve the disorder of energy balance as a consequence of suppressing the excessive intake of calories by reducing the absorption of lipids in patients with metabolic syndrome.