Study of Serum Immunoglobulin Levels: Complements C3 and C4 in Vitiligo Patients in Northern India
Study of Serum Immunoglobulin Levels: Complements C3 and C4 in Vitiligo Patients in Northern India
复制标题
血清免疫球蛋白水平研究：印度北部白癜风患者补充 C3 和 C4
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Pandey
中科院分区：
文献类型：
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作者：
U. Singh;S. Singh;S. Pandey
白癜风是一种获得性的、特异性的、常见的、常可遗传的色素脱失性皮肤病，其特征为进行性的、界限清楚的、缺乏可识别的黑素细胞的乳白色皮肤斑。它是多因素和多基因的。确切的病理学仍然难以捉摸;然而，已经提出了几种理论来解释这种疾病中表皮黑素细胞的损失。这些理论都不能完全解释这种疾病的所有临床和实验观察。本研究旨在探讨体液免疫在白癜风发病中的作用。比较白癜风患者与正常对照组血清免疫球蛋白谱。本研究从印度北方邦瓦拉纳西的Sunderlal爵士医院皮肤性病科和Banaras印度大学医院随机招募了200名白癜风患者和75名对照。补体C3、C4和免疫球蛋白IgG、伊加、IgM用免疫球蛋白试剂盒比浊法测定。
Vitiligo is an acquired, specific, common, often heritable, depigmenting skin disorder characterized by progressive, well-circumscribed milky cutaneous macules devoid of identifiable melanocytes. It is multifactorial and polygenic. The precise pathology remains elusive; however, several theories have been proposed to explain the loss of epidermal melanocytes in this disorder. None of these theories can completely explain all the clinical and experimental observations made in this disorder. The present study was aimed to find out the role of humoral immunity in the pathogenesis of vitiligo. The serum immunoglobulin profiles of vitiligo patients were compared with that of normal healthy controls. Two hundred vitiligo patients and 75 controls were recruited randomly from the Department of Dermatology and Venereology, Sir Sunderlal Hospital, and Banaras Hindu University Hospital, Varanasi, UP, India, for this study. Complements C3 and C4 and immunoglobulins IgG, IgA, and IgM were estimated by turbidometric method using immunoglobulin kit.
DOI：
10.1034/j.1600-0749.2003.00032.x
发表时间：
2003-06-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
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作者：
Alkhateeb, A;Fain, PR;Spritz, RA
通讯作者：
Spritz, RA